A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:c8f3b9c35b464d2190cfc98087f0f04d2021-12-01T12:12:25ZA Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer2234-943X10.3389/fonc.2021.777849https://doaj.org/article/c8f3b9c35b464d2190cfc98087f0f04d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.777849/fullhttps://doaj.org/toc/2234-943XAFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis.Soudeh Ghafouri-FardTayybeh KhoshbakhtBashdar Mahmud HussenMohammad TaheriMohammad TaheriMajid MokhtariFrontiers Media S.A.articleAFAP1-AS1cancerbiomarkerexpressionncRNANeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
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DOAJ |
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EN |
| topic |
AFAP1-AS1 cancer biomarker expression ncRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
AFAP1-AS1 cancer biomarker expression ncRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Soudeh Ghafouri-Fard Tayybeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Majid Mokhtari A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer |
| description |
AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis. |
| format |
article |
| author |
Soudeh Ghafouri-Fard Tayybeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Majid Mokhtari |
| author_facet |
Soudeh Ghafouri-Fard Tayybeh Khoshbakht Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Majid Mokhtari |
| author_sort |
Soudeh Ghafouri-Fard |
| title |
A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer |
| title_short |
A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer |
| title_full |
A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer |
| title_fullStr |
A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer |
| title_full_unstemmed |
A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer |
| title_sort |
review on the role of afap1-as1 in the pathoetiology of cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/c8f3b9c35b464d2190cfc98087f0f04d |
| work_keys_str_mv |
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