The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

Abstract Supplemental vitamin D can reduce the risk and mortality of viral pneumonia. The relationship between 25 hydroxyvitamin D [25(OH)D] levels and the severity and mortality of Coronavirus disease 2019 (COVID-19) was evaluated. In this cross-sectional study, the admitted patients with COVID-19...

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Autores principales:	Maryam Vasheghani, Nasrin Jannati, Parvaneh Baghaei, Mitra Rezaei, Roqayeh Aliyari, Majid Marjani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8f6f39ac57f49ccb35d68a617501cf3
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spelling	oai:doaj.org-article:c8f6f39ac57f49ccb35d68a617501cf32021-12-02T19:04:11ZThe relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality10.1038/s41598-021-97017-92045-2322https://doaj.org/article/c8f6f39ac57f49ccb35d68a617501cf32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97017-9https://doaj.org/toc/2045-2322Abstract Supplemental vitamin D can reduce the risk and mortality of viral pneumonia. The relationship between 25 hydroxyvitamin D [25(OH)D] levels and the severity and mortality of Coronavirus disease 2019 (COVID-19) was evaluated. In this cross-sectional study, the admitted patients with COVID-19 were categorized as mild, moderate, severe, and critical based on clinical and radiologic characteristics. Calcium, phosphorus, albumin, creatinine, and serum 25(OH)D were measured and their correlation with the severity of disease and mortality were analyzed. During 2 months, 508 patients (442 patients in general wards and 66 patients in the intensive care unit (ICU)) were included. The participants were 56 ± 17 years old (52% male, 37% with comorbidity). Concerning severity, 13%, 42%, 36%, and 9% had mild, moderate, severe, and critical diseases, respectively. The mortality rate was 10.8%. Admission to ICU, severity of disease and mortality decreased significantly across quartiles of 25(OH)D. According to multivariate logistic regression analysis, disease mortality had a positive correlation with age and had a negative correlation with the serum level of 25(OH)D, calcium, and albumin. In hospitalized patients with COVID-19, low 25(OH)D was associated with severe disease and increased ICU admission and mortality rate.Maryam VasheghaniNasrin JannatiParvaneh BaghaeiMitra RezaeiRoqayeh AliyariMajid MarjaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maryam Vasheghani Nasrin Jannati Parvaneh Baghaei Mitra Rezaei Roqayeh Aliyari Majid Marjani The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality
description	Abstract Supplemental vitamin D can reduce the risk and mortality of viral pneumonia. The relationship between 25 hydroxyvitamin D [25(OH)D] levels and the severity and mortality of Coronavirus disease 2019 (COVID-19) was evaluated. In this cross-sectional study, the admitted patients with COVID-19 were categorized as mild, moderate, severe, and critical based on clinical and radiologic characteristics. Calcium, phosphorus, albumin, creatinine, and serum 25(OH)D were measured and their correlation with the severity of disease and mortality were analyzed. During 2 months, 508 patients (442 patients in general wards and 66 patients in the intensive care unit (ICU)) were included. The participants were 56 ± 17 years old (52% male, 37% with comorbidity). Concerning severity, 13%, 42%, 36%, and 9% had mild, moderate, severe, and critical diseases, respectively. The mortality rate was 10.8%. Admission to ICU, severity of disease and mortality decreased significantly across quartiles of 25(OH)D. According to multivariate logistic regression analysis, disease mortality had a positive correlation with age and had a negative correlation with the serum level of 25(OH)D, calcium, and albumin. In hospitalized patients with COVID-19, low 25(OH)D was associated with severe disease and increased ICU admission and mortality rate.
format	article
author	Maryam Vasheghani Nasrin Jannati Parvaneh Baghaei Mitra Rezaei Roqayeh Aliyari Majid Marjani
author_facet	Maryam Vasheghani Nasrin Jannati Parvaneh Baghaei Mitra Rezaei Roqayeh Aliyari Majid Marjani
author_sort	Maryam Vasheghani
title	The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality
title_short	The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality
title_full	The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality
title_fullStr	The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality
title_full_unstemmed	The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality
title_sort	relationship between serum 25-hydroxyvitamin d levels and the severity of covid-19 disease and its mortality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8f6f39ac57f49ccb35d68a617501cf3
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The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

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