The role of thyrostimulin and its potential clinical significance

Thyrostimulin is a glycoprotein heterodimer of GPA2 and GPB5, first described in 2002. It is involved in the physiological function of several tissues. Moreover, evidence points towards the ability of thyrostimulin’s individual monomers to induce a biological effect, which could denote the circulato...

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Autores principales:	Karponis Dimitrios, Ananth S.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	thyrostimulin glycoprotein hormone thyroid gland amphioxus Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c8fc1cc6ae5c40b995f0bf032db090f0
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spelling	oai:doaj.org-article:c8fc1cc6ae5c40b995f0bf032db090f02021-12-02T17:49:19ZThe role of thyrostimulin and its potential clinical significance1336-032910.1515/enr-2017-0012https://doaj.org/article/c8fc1cc6ae5c40b995f0bf032db090f02017-04-01T00:00:00Zhttps://doi.org/10.1515/enr-2017-0012https://doaj.org/toc/1336-0329Thyrostimulin is a glycoprotein heterodimer of GPA2 and GPB5, first described in 2002. It is involved in the physiological function of several tissues. Moreover, evidence points towards the ability of thyrostimulin’s individual monomers to induce a biological effect, which could denote the circulatory/systemic effects of the molecule when found in higher concentrations. From the evolutionary point of view, thyrostimulin shares a binding epitope with the thyroid-stimulating hormone for the thyroid stimulating hormone receptor, whilst possessing affinity for another unique binding site on the same receptor. Although thyrostimulin can be involved in the hypothalamicpituitary- thyroid axis, its presence in various tissues in an eclectic array of different species renders it multifunctional. From weight loss via increasing metabolic rate to progression of cancer in human ovaries, it is certainly not a signaling molecule to overlook. Furthermore, thyrostimulin has been implicated in bone metabolism, acute illness, and reproductive function. In summary, to our knowledge, this is the first review dealing with the physiological role of thyrostimulin and its potential applications in the clinical practice.Karponis DimitriosAnanth S.Sciendoarticlethyrostimulinglycoprotein hormonethyroid glandamphioxusDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 51, Iss 2, Pp 117-128 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyrostimulin glycoprotein hormone thyroid gland amphioxus Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	thyrostimulin glycoprotein hormone thyroid gland amphioxus Diseases of the endocrine glands. Clinical endocrinology RC648-665 Karponis Dimitrios Ananth S. The role of thyrostimulin and its potential clinical significance
description	Thyrostimulin is a glycoprotein heterodimer of GPA2 and GPB5, first described in 2002. It is involved in the physiological function of several tissues. Moreover, evidence points towards the ability of thyrostimulin’s individual monomers to induce a biological effect, which could denote the circulatory/systemic effects of the molecule when found in higher concentrations. From the evolutionary point of view, thyrostimulin shares a binding epitope with the thyroid-stimulating hormone for the thyroid stimulating hormone receptor, whilst possessing affinity for another unique binding site on the same receptor. Although thyrostimulin can be involved in the hypothalamicpituitary- thyroid axis, its presence in various tissues in an eclectic array of different species renders it multifunctional. From weight loss via increasing metabolic rate to progression of cancer in human ovaries, it is certainly not a signaling molecule to overlook. Furthermore, thyrostimulin has been implicated in bone metabolism, acute illness, and reproductive function. In summary, to our knowledge, this is the first review dealing with the physiological role of thyrostimulin and its potential applications in the clinical practice.
format	article
author	Karponis Dimitrios Ananth S.
author_facet	Karponis Dimitrios Ananth S.
author_sort	Karponis Dimitrios
title	The role of thyrostimulin and its potential clinical significance
title_short	The role of thyrostimulin and its potential clinical significance
title_full	The role of thyrostimulin and its potential clinical significance
title_fullStr	The role of thyrostimulin and its potential clinical significance
title_full_unstemmed	The role of thyrostimulin and its potential clinical significance
title_sort	role of thyrostimulin and its potential clinical significance
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/c8fc1cc6ae5c40b995f0bf032db090f0
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The role of thyrostimulin and its potential clinical significance

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