Zebrafish: An in vivo model for the study of neurological diseases

J D Best, Wendy K AldertonSummit (Cambridge) Ltd., Beach Drive, Cambridge, UKAbstract: As the population ages, there is a growing need for effective therapies for the treatment of neurological diseases. A limited number of therapeutics are currently available to improve cognitive function and resear...

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Autores principales:	J D Best, Wendy K Alderton
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c8ffa0def81f44648c917d916be30c05
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spelling	oai:doaj.org-article:c8ffa0def81f44648c917d916be30c052021-12-02T11:13:17ZZebrafish: An in vivo model for the study of neurological diseases1176-63281178-2021https://doaj.org/article/c8ffa0def81f44648c917d916be30c052008-06-01T00:00:00Zhttp://www.dovepress.com/zebrafish-an-in-vivo-model-for-the-study-of-neurological-diseases-a1867https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021J D Best, Wendy K AldertonSummit (Cambridge) Ltd., Beach Drive, Cambridge, UKAbstract: As the population ages, there is a growing need for effective therapies for the treatment of neurological diseases. A limited number of therapeutics are currently available to improve cognitive function and research is limited by the need for in vivo models. Zebrafish have recently become a focus of neurobehavioral studies since larvae display neuropathological and behavioral phenotypes that are quantifiable and relate to those seen in man. Due to the small size of Zebrafish larvae, assays can be undertaken in 96 well plates and as the larvae can live in as little as 200 &mu;l of fluid, only a few milligrams of compound are needed for screening. Thus in vivo analysis of the effects of compounds can be undertaken at much earlier stages in the drug discovery process. This review will look at the utility of the zebrafish in the study of neurological diseases and its role in improving the throughput of candidate compounds in in vivo screens.Keywords: Zebrafish, aging, neurobehavior, neurological disease J D BestWendy K AldertonDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 3, Pp 567-576 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 J D Best Wendy K Alderton Zebrafish: An in vivo model for the study of neurological diseases
description	J D Best, Wendy K AldertonSummit (Cambridge) Ltd., Beach Drive, Cambridge, UKAbstract: As the population ages, there is a growing need for effective therapies for the treatment of neurological diseases. A limited number of therapeutics are currently available to improve cognitive function and research is limited by the need for in vivo models. Zebrafish have recently become a focus of neurobehavioral studies since larvae display neuropathological and behavioral phenotypes that are quantifiable and relate to those seen in man. Due to the small size of Zebrafish larvae, assays can be undertaken in 96 well plates and as the larvae can live in as little as 200 &mu;l of fluid, only a few milligrams of compound are needed for screening. Thus in vivo analysis of the effects of compounds can be undertaken at much earlier stages in the drug discovery process. This review will look at the utility of the zebrafish in the study of neurological diseases and its role in improving the throughput of candidate compounds in in vivo screens.Keywords: Zebrafish, aging, neurobehavior, neurological disease
format	article
author	J D Best Wendy K Alderton
author_facet	J D Best Wendy K Alderton
author_sort	J D Best
title	Zebrafish: An in vivo model for the study of neurological diseases
title_short	Zebrafish: An in vivo model for the study of neurological diseases
title_full	Zebrafish: An in vivo model for the study of neurological diseases
title_fullStr	Zebrafish: An in vivo model for the study of neurological diseases
title_full_unstemmed	Zebrafish: An in vivo model for the study of neurological diseases
title_sort	zebrafish: an in vivo model for the study of neurological diseases
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/c8ffa0def81f44648c917d916be30c05
work_keys_str_mv	AT jdbest zebrafishaninvivomodelforthestudyofneurologicaldiseases AT wendykalderton zebrafishaninvivomodelforthestudyofneurologicaldiseases
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Zebrafish: An in vivo model for the study of neurological diseases

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