Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

Islet transplantation is a feasible approach to treat type I diabetes, however inflammation and poor vascularisation impair long-term engraftment. Here the authors show that incorporating human amniotic epithelial cells into islet organoids improves engraftment and function of organoids, through enh...

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Autores principales:	Fanny Lebreton, Vanessa Lavallard, Kevin Bellofatto, Romain Bonnet, Charles H. Wassmer, Lisa Perez, Vakhtang Kalandadze, Antonia Follenzi, Michel Boulvain, Julie Kerr-Conte, David J. Goodman, Domenico Bosco, Thierry Berney, Ekaterine Berishvili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c901153a0f93424598e6b1d1ec7d9eba
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spelling	oai:doaj.org-article:c901153a0f93424598e6b1d1ec7d9eba2021-12-02T15:35:27ZInsulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes10.1038/s41467-019-12472-32041-1723https://doaj.org/article/c901153a0f93424598e6b1d1ec7d9eba2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12472-3https://doaj.org/toc/2041-1723Islet transplantation is a feasible approach to treat type I diabetes, however inflammation and poor vascularisation impair long-term engraftment. Here the authors show that incorporating human amniotic epithelial cells into islet organoids improves engraftment and function of organoids, through enhanced revascularisation.Fanny LebretonVanessa LavallardKevin BellofattoRomain BonnetCharles H. WassmerLisa PerezVakhtang KalandadzeAntonia FollenziMichel BoulvainJulie Kerr-ConteDavid J. GoodmanDomenico BoscoThierry BerneyEkaterine BerishviliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fanny Lebreton Vanessa Lavallard Kevin Bellofatto Romain Bonnet Charles H. Wassmer Lisa Perez Vakhtang Kalandadze Antonia Follenzi Michel Boulvain Julie Kerr-Conte David J. Goodman Domenico Bosco Thierry Berney Ekaterine Berishvili Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
description	Islet transplantation is a feasible approach to treat type I diabetes, however inflammation and poor vascularisation impair long-term engraftment. Here the authors show that incorporating human amniotic epithelial cells into islet organoids improves engraftment and function of organoids, through enhanced revascularisation.
format	article
author	Fanny Lebreton Vanessa Lavallard Kevin Bellofatto Romain Bonnet Charles H. Wassmer Lisa Perez Vakhtang Kalandadze Antonia Follenzi Michel Boulvain Julie Kerr-Conte David J. Goodman Domenico Bosco Thierry Berney Ekaterine Berishvili
author_facet	Fanny Lebreton Vanessa Lavallard Kevin Bellofatto Romain Bonnet Charles H. Wassmer Lisa Perez Vakhtang Kalandadze Antonia Follenzi Michel Boulvain Julie Kerr-Conte David J. Goodman Domenico Bosco Thierry Berney Ekaterine Berishvili
author_sort	Fanny Lebreton
title	Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
title_short	Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
title_full	Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
title_fullStr	Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
title_full_unstemmed	Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
title_sort	insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c901153a0f93424598e6b1d1ec7d9eba
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Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

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