Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer

Abstract The comparison of chemical and histopathological data obtained from the analysis of excised tumor fragments oral squamous cell carcinoma (OSCC) with the demographic and clinical evolution data is an effective strategy scarcely explored in OSCC studies. The aim was to analyze OSCC tissues fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aricia Leone Evangelista Monteiro de Assis, Anderson Barros Archanjo, Raul C. Maranhão, Suzanny O. Mendes, Rafael P. de Souza, Rafael de Cicco, Mayara M. de Oliveira, Aline R. Borçoi, Lucas de L. Maia, Fabio D. Nunes, Marcelo dos Santos, Leonardo O. Trivilin, Christiano J. G. Pinheiro, Adriana M. Álvares-da-Silva, Breno Valentim Nogueira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9020de74e6e480ab826bfc5dd6e7a8b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9020de74e6e480ab826bfc5dd6e7a8b
record_format	dspace
spelling	oai:doaj.org-article:c9020de74e6e480ab826bfc5dd6e7a8b2021-11-21T12:23:39ZChlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer10.1038/s41598-021-01753-x2045-2322https://doaj.org/article/c9020de74e6e480ab826bfc5dd6e7a8b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01753-xhttps://doaj.org/toc/2045-2322Abstract The comparison of chemical and histopathological data obtained from the analysis of excised tumor fragments oral squamous cell carcinoma (OSCC) with the demographic and clinical evolution data is an effective strategy scarcely explored in OSCC studies. The aim was to analyze OSCC tissues for protein expression of enzymes related to oxidative stress and DNA repair and trace elements as candidates as markers of tumor aggressiveness and prognosis. Tumor fragments from 78 OSCC patients that had undergone ablative surgery were qualitatively analyzed by synchrotron micro-X-ray fluorescence for trace elements. Protein expression of SOD-1, Trx, Ref-1 and OGG1/2 was performed by immunohistochemistry. Sociodemographic, clinical, and histopathological data were obtained from 4-year follow-up records. Disease relapse was highest in patients with the presence of chlorine and chromium and lowest in those with tumors with high OGG1/2 expression. High expression of SOD-1, Trx, and Ref-1 was determinant of the larger tumor. Presence of trace elements can be markers of disease prognosis. High expression of enzymes related to oxidative stress or to DNA repair can be either harmful by stimulating tumor growth or beneficial by diminishing relapse rates. Interference on these players may bring novel strategies for the therapeutic management of OSCC patients.Aricia Leone Evangelista Monteiro de AssisAnderson Barros ArchanjoRaul C. MaranhãoSuzanny O. MendesRafael P. de SouzaRafael de CiccoMayara M. de OliveiraAline R. BorçoiLucas de L. MaiaFabio D. NunesMarcelo dos SantosLeonardo O. TrivilinChristiano J. G. PinheiroAdriana M. Álvares-da-SilvaBreno Valentim NogueiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aricia Leone Evangelista Monteiro de Assis Anderson Barros Archanjo Raul C. Maranhão Suzanny O. Mendes Rafael P. de Souza Rafael de Cicco Mayara M. de Oliveira Aline R. Borçoi Lucas de L. Maia Fabio D. Nunes Marcelo dos Santos Leonardo O. Trivilin Christiano J. G. Pinheiro Adriana M. Álvares-da-Silva Breno Valentim Nogueira Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
description	Abstract The comparison of chemical and histopathological data obtained from the analysis of excised tumor fragments oral squamous cell carcinoma (OSCC) with the demographic and clinical evolution data is an effective strategy scarcely explored in OSCC studies. The aim was to analyze OSCC tissues for protein expression of enzymes related to oxidative stress and DNA repair and trace elements as candidates as markers of tumor aggressiveness and prognosis. Tumor fragments from 78 OSCC patients that had undergone ablative surgery were qualitatively analyzed by synchrotron micro-X-ray fluorescence for trace elements. Protein expression of SOD-1, Trx, Ref-1 and OGG1/2 was performed by immunohistochemistry. Sociodemographic, clinical, and histopathological data were obtained from 4-year follow-up records. Disease relapse was highest in patients with the presence of chlorine and chromium and lowest in those with tumors with high OGG1/2 expression. High expression of SOD-1, Trx, and Ref-1 was determinant of the larger tumor. Presence of trace elements can be markers of disease prognosis. High expression of enzymes related to oxidative stress or to DNA repair can be either harmful by stimulating tumor growth or beneficial by diminishing relapse rates. Interference on these players may bring novel strategies for the therapeutic management of OSCC patients.
format	article
author	Aricia Leone Evangelista Monteiro de Assis Anderson Barros Archanjo Raul C. Maranhão Suzanny O. Mendes Rafael P. de Souza Rafael de Cicco Mayara M. de Oliveira Aline R. Borçoi Lucas de L. Maia Fabio D. Nunes Marcelo dos Santos Leonardo O. Trivilin Christiano J. G. Pinheiro Adriana M. Álvares-da-Silva Breno Valentim Nogueira
author_facet	Aricia Leone Evangelista Monteiro de Assis Anderson Barros Archanjo Raul C. Maranhão Suzanny O. Mendes Rafael P. de Souza Rafael de Cicco Mayara M. de Oliveira Aline R. Borçoi Lucas de L. Maia Fabio D. Nunes Marcelo dos Santos Leonardo O. Trivilin Christiano J. G. Pinheiro Adriana M. Álvares-da-Silva Breno Valentim Nogueira
author_sort	Aricia Leone Evangelista Monteiro de Assis
title	Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
title_short	Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
title_full	Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
title_fullStr	Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
title_full_unstemmed	Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
title_sort	chlorine, chromium, proteins of oxidative stress and dna repair pathways are related to prognosis in oral cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9020de74e6e480ab826bfc5dd6e7a8b
work_keys_str_mv	AT aricialeoneevangelistamonteirodeassis chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT andersonbarrosarchanjo chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT raulcmaranhao chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT suzannyomendes chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT rafaelpdesouza chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT rafaeldecicco chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT mayaramdeoliveira chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT alinerborcoi chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT lucasdelmaia chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT fabiodnunes chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT marcelodossantos chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT leonardootrivilin chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT christianojgpinheiro chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT adrianamalvaresdasilva chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer AT brenovalentimnogueira chlorinechromiumproteinsofoxidativestressanddnarepairpathwaysarerelatedtoprognosisinoralcancer
_version_	1718419092846673920

Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer

Ejemplares similares