Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer

Phosphodiesterase-5 (PDE5) inhibitors have been suggested to have an anti-tumor effect and block surgery-induced immunosuppression. Here, the authors show that postdiagnostic use of PDE5 inhibitors is associated with a decreased risk of colorectal cancerspecific mortality as well as a decreased risk...

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Autores principales:	Wuqing Huang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9027a3053744a7f8d8ec74a50045c97
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spelling	oai:doaj.org-article:c9027a3053744a7f8d8ec74a50045c972021-12-02T17:45:00ZPhosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer10.1038/s41467-020-17028-42041-1723https://doaj.org/article/c9027a3053744a7f8d8ec74a50045c972020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17028-4https://doaj.org/toc/2041-1723Phosphodiesterase-5 (PDE5) inhibitors have been suggested to have an anti-tumor effect and block surgery-induced immunosuppression. Here, the authors show that postdiagnostic use of PDE5 inhibitors is associated with a decreased risk of colorectal cancerspecific mortality as well as a decreased risk of metastasis.Wuqing HuangJan SundquistKristina SundquistJianguang JiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wuqing Huang Jan Sundquist Kristina Sundquist Jianguang Ji Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
description	Phosphodiesterase-5 (PDE5) inhibitors have been suggested to have an anti-tumor effect and block surgery-induced immunosuppression. Here, the authors show that postdiagnostic use of PDE5 inhibitors is associated with a decreased risk of colorectal cancerspecific mortality as well as a decreased risk of metastasis.
format	article
author	Wuqing Huang Jan Sundquist Kristina Sundquist Jianguang Ji
author_facet	Wuqing Huang Jan Sundquist Kristina Sundquist Jianguang Ji
author_sort	Wuqing Huang
title	Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
title_short	Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
title_full	Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
title_fullStr	Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
title_full_unstemmed	Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
title_sort	phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c9027a3053744a7f8d8ec74a50045c97
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Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer

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