Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and...
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Nature Portfolio
2017
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oai:doaj.org-article:c9087c97e4584399b00b49105c3d6c1d2021-12-02T17:06:06ZHepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance10.1038/s41467-017-02074-22041-1723https://doaj.org/article/c9087c97e4584399b00b49105c3d6c1d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02074-2https://doaj.org/toc/2041-1723During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production.Xavier BrenachotGiorgio RamadoriRafael M. IorisChristelle Veyrat-DurebexJordi AltirribaEbru ArasSanda LjubicicDaisuke KohnoSalvatore FabbianoSophie ClementNicolas GoossensMirko TrajkovskiSheila HarrochFrancesco NegroRoberto CoppariNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Xavier Brenachot Giorgio Ramadori Rafael M. Ioris Christelle Veyrat-Durebex Jordi Altirriba Ebru Aras Sanda Ljubicic Daisuke Kohno Salvatore Fabbiano Sophie Clement Nicolas Goossens Mirko Trajkovski Sheila Harroch Francesco Negro Roberto Coppari Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| description |
During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production. |
| format |
article |
| author |
Xavier Brenachot Giorgio Ramadori Rafael M. Ioris Christelle Veyrat-Durebex Jordi Altirriba Ebru Aras Sanda Ljubicic Daisuke Kohno Salvatore Fabbiano Sophie Clement Nicolas Goossens Mirko Trajkovski Sheila Harroch Francesco Negro Roberto Coppari |
| author_facet |
Xavier Brenachot Giorgio Ramadori Rafael M. Ioris Christelle Veyrat-Durebex Jordi Altirriba Ebru Aras Sanda Ljubicic Daisuke Kohno Salvatore Fabbiano Sophie Clement Nicolas Goossens Mirko Trajkovski Sheila Harroch Francesco Negro Roberto Coppari |
| author_sort |
Xavier Brenachot |
| title |
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| title_short |
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| title_full |
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| title_fullStr |
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| title_full_unstemmed |
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| title_sort |
hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/c9087c97e4584399b00b49105c3d6c1d |
| work_keys_str_mv |
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