Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion

Shan-hui Hsu,1 Lien-Guo Dai,2 Yu-Min Hung,1 Niann-Tzyy Dai3 1Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of China; 2Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China; 3Division of Plasti...

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Autores principales:	Hsu SH, Dai L, Hung YM, Dai N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	adhesion tendon polyurethane postoperative adhesion Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c90d83eb7db24e3a8e72918c2f74d6ce
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spelling	oai:doaj.org-article:c90d83eb7db24e3a8e72918c2f74d6ce2021-12-02T00:46:29ZEvaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion1178-2013https://doaj.org/article/c90d83eb7db24e3a8e72918c2f74d6ce2018-09-01T00:00:00Zhttps://www.dovepress.com/evaluation-and-characterization-of-waterborne-biodegradable-polyuretha-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shan-hui Hsu,1 Lien-Guo Dai,2 Yu-Min Hung,1 Niann-Tzyy Dai3 1Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of China; 2Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China; 3Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China Background: Tendon adhesion is a serious problem and it affects tendon gliding and joint motion. Although recent studies have yielded promising results in developing anti-adhesion materials, there are still many problems. Polycaprolactone (PCL)-based polyurethane (PU) has good mechanical properties and biocompatibility, and it has a potential in anti-adhesion applications. Materials and methods: In this study, a series of waterborne biodegradable polyurethane (WBPU) films with different ratios of ionic groups were synthesized. In order to select an effective anti-adhesion film, the WBPU films were cast and characterized for physicochemical properties and biocompatibility. Results: All WBPU films were non-cytotoxic in the cell viability test and had suitable physicochemical and mechanical properties based on the measurement of zeta potential, water contact angle, mechanical properties, water absorption, thickness change, and gelatin test. To evaluate the anti-adhesion effect, severely injured tendons of rabbits were sutured with the modified Kessler core suture technique and WBPU films were then wrapped around the tendon. Implantation in rabbits showed that the WBPU film had better anti-adhesion effect than PCL films and the untreated control, and demonstrated no significant difference in the anti-adhesion performance from the commercial product Seprafilm based on gross evaluation, histological analysis, and biomechanical assessment. Conclusion: Compared to Seprafilm and PCL applied in the tendon anti-adhesion, WBPU had better mechanical properties, low inflammatory reaction, and a proper degradation interval. Keywords: adhesion, tendon, polyurethane, postoperative adhesionHsu SHDai LHung YMDai NDove Medical Pressarticleadhesiontendonpolyurethanepostoperative adhesionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5485-5497 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	adhesion tendon polyurethane postoperative adhesion Medicine (General) R5-920
spellingShingle	adhesion tendon polyurethane postoperative adhesion Medicine (General) R5-920 Hsu SH Dai L Hung YM Dai N Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
description	Shan-hui Hsu,1 Lien-Guo Dai,2 Yu-Min Hung,1 Niann-Tzyy Dai3 1Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of China; 2Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China; 3Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China Background: Tendon adhesion is a serious problem and it affects tendon gliding and joint motion. Although recent studies have yielded promising results in developing anti-adhesion materials, there are still many problems. Polycaprolactone (PCL)-based polyurethane (PU) has good mechanical properties and biocompatibility, and it has a potential in anti-adhesion applications. Materials and methods: In this study, a series of waterborne biodegradable polyurethane (WBPU) films with different ratios of ionic groups were synthesized. In order to select an effective anti-adhesion film, the WBPU films were cast and characterized for physicochemical properties and biocompatibility. Results: All WBPU films were non-cytotoxic in the cell viability test and had suitable physicochemical and mechanical properties based on the measurement of zeta potential, water contact angle, mechanical properties, water absorption, thickness change, and gelatin test. To evaluate the anti-adhesion effect, severely injured tendons of rabbits were sutured with the modified Kessler core suture technique and WBPU films were then wrapped around the tendon. Implantation in rabbits showed that the WBPU film had better anti-adhesion effect than PCL films and the untreated control, and demonstrated no significant difference in the anti-adhesion performance from the commercial product Seprafilm based on gross evaluation, histological analysis, and biomechanical assessment. Conclusion: Compared to Seprafilm and PCL applied in the tendon anti-adhesion, WBPU had better mechanical properties, low inflammatory reaction, and a proper degradation interval. Keywords: adhesion, tendon, polyurethane, postoperative adhesion
format	article
author	Hsu SH Dai L Hung YM Dai N
author_facet	Hsu SH Dai L Hung YM Dai N
author_sort	Hsu SH
title	Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
title_short	Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
title_full	Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
title_fullStr	Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
title_full_unstemmed	Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
title_sort	evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c90d83eb7db24e3a8e72918c2f74d6ce
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Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion

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