The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD

Abstract Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inf...

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Autores principales:	Muhammad Fachri, Mochammad Hatta, Muhammad Nasrum Massi, Arif Santoso, Tri Ariguntar Wikanningtyas, Ressy Dwiyanti, Ade Rifka Junita, Muhammad Reza Primaguna, Muhammad Sabir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c90f9b35e93d4471aa2fb0e17ab076d8
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spelling	oai:doaj.org-article:c90f9b35e93d4471aa2fb0e17ab076d82021-12-05T12:13:05ZThe strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD10.1038/s41598-021-02615-22045-2322https://doaj.org/article/c90f9b35e93d4471aa2fb0e17ab076d82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02615-2https://doaj.org/toc/2045-2322Abstract Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inflammatory cells of COPD patients. ADAM33 has been reported to be involved in the pathogenesis of COPD in East Asia by affecting airway inflammation and other immune responses. The aim of this study was to determine the potential role of ADAM33 (mRNA and soluble levels) as a biomarker of inflammation in COPD patients. This is a case control study using consecutive sampling. The COPD case and control (non-COPD) groups comprised 37 and 29 patients, respectively. We used univariate analysis to assess differences in the parameters between the groups and bivariate analysis to non-parametrically compare these parameters between the two groups. We observed significantly higher mRNA levels of ADAM33 in the COPD patients (10.39 ± 1.76) as compared to that in the non-COPD individuals (6.93 ± 0.39; P < 0.001). The levels of soluble ADAM33 were also significantly higher in the COPD patients (2.188 ± 1.142 ng/ml) compared to the non-COPD individuals (0.487 ± 0.105 ng/ml; P < 0.001). The mRNA and soluble ADAM33 levels were significantly higher in COPD patients compared to those in the parameter-matched non-COPD individuals. Thus, ADAM33 is a potential biomarker and treatment for inflammation in COPD patients.Muhammad FachriMochammad HattaMuhammad Nasrum MassiArif SantosoTri Ariguntar WikanningtyasRessy DwiyantiAde Rifka JunitaMuhammad Reza PrimagunaMuhammad SabirNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammad Fachri Mochammad Hatta Muhammad Nasrum Massi Arif Santoso Tri Ariguntar Wikanningtyas Ressy Dwiyanti Ade Rifka Junita Muhammad Reza Primaguna Muhammad Sabir The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
description	Abstract Airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is an amplified response of the normal immune system that occurs as a result of chronic irritation by toxic substances, such as cigarette smoke. This leads to the characteristic pathological changes in the inflammatory cells of COPD patients. ADAM33 has been reported to be involved in the pathogenesis of COPD in East Asia by affecting airway inflammation and other immune responses. The aim of this study was to determine the potential role of ADAM33 (mRNA and soluble levels) as a biomarker of inflammation in COPD patients. This is a case control study using consecutive sampling. The COPD case and control (non-COPD) groups comprised 37 and 29 patients, respectively. We used univariate analysis to assess differences in the parameters between the groups and bivariate analysis to non-parametrically compare these parameters between the two groups. We observed significantly higher mRNA levels of ADAM33 in the COPD patients (10.39 ± 1.76) as compared to that in the non-COPD individuals (6.93 ± 0.39; P < 0.001). The levels of soluble ADAM33 were also significantly higher in the COPD patients (2.188 ± 1.142 ng/ml) compared to the non-COPD individuals (0.487 ± 0.105 ng/ml; P < 0.001). The mRNA and soluble ADAM33 levels were significantly higher in COPD patients compared to those in the parameter-matched non-COPD individuals. Thus, ADAM33 is a potential biomarker and treatment for inflammation in COPD patients.
format	article
author	Muhammad Fachri Mochammad Hatta Muhammad Nasrum Massi Arif Santoso Tri Ariguntar Wikanningtyas Ressy Dwiyanti Ade Rifka Junita Muhammad Reza Primaguna Muhammad Sabir
author_facet	Muhammad Fachri Mochammad Hatta Muhammad Nasrum Massi Arif Santoso Tri Ariguntar Wikanningtyas Ressy Dwiyanti Ade Rifka Junita Muhammad Reza Primaguna Muhammad Sabir
author_sort	Muhammad Fachri
title	The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
title_short	The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
title_full	The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
title_fullStr	The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
title_full_unstemmed	The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD
title_sort	strong correlation between adam33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of copd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c90f9b35e93d4471aa2fb0e17ab076d8
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The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD

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