TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging

Activation of thermogenic beige adipocytes within white adipose tissue increases energy expenditure. Here, the authors show that expression of TonEBP in adipocytes is increased when mice are fed a high fat diet and that it suppresses expression of beta3-adrenoreceptor.

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Autores principales:	Hwan Hee Lee, Seung Min An, Byeong Jin Ye, Jun Ho Lee, Eun Jin Yoo, Gyu Won Jeong, Hyun Je Kang, Assim A. Alfadda, Sun Woo Lim, Jiyoung Park, Whaseon Lee-Kwon, Jae Bum Kim, Soo Youn Choi, Hyug Moo Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c910c758701b4d8199d390804df2fbb8
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spelling	oai:doaj.org-article:c910c758701b4d8199d390804df2fbb82021-12-02T16:58:26ZTonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging10.1038/s41467-019-11302-w2041-1723https://doaj.org/article/c910c758701b4d8199d390804df2fbb82019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11302-whttps://doaj.org/toc/2041-1723Activation of thermogenic beige adipocytes within white adipose tissue increases energy expenditure. Here, the authors show that expression of TonEBP in adipocytes is increased when mice are fed a high fat diet and that it suppresses expression of beta3-adrenoreceptor.Hwan Hee LeeSeung Min AnByeong Jin YeJun Ho LeeEun Jin YooGyu Won JeongHyun Je KangAssim A. AlfaddaSun Woo LimJiyoung ParkWhaseon Lee-KwonJae Bum KimSoo Youn ChoiHyug Moo KwonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hwan Hee Lee Seung Min An Byeong Jin Ye Jun Ho Lee Eun Jin Yoo Gyu Won Jeong Hyun Je Kang Assim A. Alfadda Sun Woo Lim Jiyoung Park Whaseon Lee-Kwon Jae Bum Kim Soo Youn Choi Hyug Moo Kwon TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
description	Activation of thermogenic beige adipocytes within white adipose tissue increases energy expenditure. Here, the authors show that expression of TonEBP in adipocytes is increased when mice are fed a high fat diet and that it suppresses expression of beta3-adrenoreceptor.
format	article
author	Hwan Hee Lee Seung Min An Byeong Jin Ye Jun Ho Lee Eun Jin Yoo Gyu Won Jeong Hyun Je Kang Assim A. Alfadda Sun Woo Lim Jiyoung Park Whaseon Lee-Kwon Jae Bum Kim Soo Youn Choi Hyug Moo Kwon
author_facet	Hwan Hee Lee Seung Min An Byeong Jin Ye Jun Ho Lee Eun Jin Yoo Gyu Won Jeong Hyun Je Kang Assim A. Alfadda Sun Woo Lim Jiyoung Park Whaseon Lee-Kwon Jae Bum Kim Soo Youn Choi Hyug Moo Kwon
author_sort	Hwan Hee Lee
title	TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
title_short	TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
title_full	TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
title_fullStr	TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
title_full_unstemmed	TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
title_sort	tonebp/nfat5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c910c758701b4d8199d390804df2fbb8
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TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging

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