The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes

The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes

A subset of inflammatory-response NF-κB target genes is activated immediately after proinflammatory stimulation. Here, the authors show that in rapidly induced genes, depletion of the elongation factor Spt5 reduces transcription initiation and TFIID–promoter association without affecting the transcr...

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Autores principales: Gil Diamant, Anat Bahat, Rivka Dikstein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c9127e56ecfe458ea2abfce9b92e4384
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spelling oai:doaj.org-article:c9127e56ecfe458ea2abfce9b92e43842021-12-02T14:38:34ZThe elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes10.1038/ncomms115472041-1723https://doaj.org/article/c9127e56ecfe458ea2abfce9b92e43842016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11547https://doaj.org/toc/2041-1723A subset of inflammatory-response NF-κB target genes is activated immediately after proinflammatory stimulation. Here, the authors show that in rapidly induced genes, depletion of the elongation factor Spt5 reduces transcription initiation and TFIID–promoter association without affecting the transcription elongation rate.Gil DiamantAnat BahatRivka DiksteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gil Diamant
Anat Bahat
Rivka Dikstein
The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
description A subset of inflammatory-response NF-κB target genes is activated immediately after proinflammatory stimulation. Here, the authors show that in rapidly induced genes, depletion of the elongation factor Spt5 reduces transcription initiation and TFIID–promoter association without affecting the transcription elongation rate.
format article
author Gil Diamant
Anat Bahat
Rivka Dikstein
author_facet Gil Diamant
Anat Bahat
Rivka Dikstein
author_sort Gil Diamant
title The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
title_short The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
title_full The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
title_fullStr The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
title_full_unstemmed The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
title_sort elongation factor spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/c9127e56ecfe458ea2abfce9b92e4384
work_keys_str_mv AT gildiamant theelongationfactorspt5facilitatestranscriptioninitiationforrapidinductionofinflammatoryresponsegenes
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AT gildiamant elongationfactorspt5facilitatestranscriptioninitiationforrapidinductionofinflammatoryresponsegenes
AT anatbahat elongationfactorspt5facilitatestranscriptioninitiationforrapidinductionofinflammatoryresponsegenes
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