Stem Cell Therapy for Retinal Degeneration: The Evidence to Date

Amit Sharma, Bithiah Grace Jaganathan Stem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, IndiaCorrespondence: Bithiah Grace JaganathanStem Cells and Cancer Biology Research Group, Department of...

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Autores principales:	Sharma A, Jaganathan BG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	retinal degeneration retinal pigment epithelial cells mesenchymal stem cells embryonic stem cells induced pluripotent stem cells retinitis pigmentosa diabetic retinopathy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c914e0b8b3784680b868f6c64b37cee9
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spelling	oai:doaj.org-article:c914e0b8b3784680b868f6c64b37cee92021-12-02T14:49:47ZStem Cell Therapy for Retinal Degeneration: The Evidence to Date1177-5491https://doaj.org/article/c914e0b8b3784680b868f6c64b37cee92021-07-01T00:00:00Zhttps://www.dovepress.com/stem-cell-therapy-for-retinal-degeneration-the-evidence-to-date-peer-reviewed-fulltext-article-BTThttps://doaj.org/toc/1177-5491Amit Sharma, Bithiah Grace Jaganathan Stem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, IndiaCorrespondence: Bithiah Grace JaganathanStem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, IndiaTel +91 361 258 2219Email bithiahgj@iitg.ac.inAbstract: There is a rise in the number of people who have vision loss due to retinal diseases, and conventional therapies for treating retinal degeneration fail to repair and regenerate the damaged retina. Several studies in animal models and human trials have explored the use of stem cells to repair the retinal tissue to improve visual acuity. In addition to the treatment of age-related macular degeneration (AMD) and diabetic retinopathy (DR), stem cell therapies were used to treat genetic diseases such as retinitis pigmentosa (RP) and Stargardt’s disease, characterized by gradual loss of photoreceptor cells in the retina. Transplantation of retinal pigment epithelial (RPE) cells derived from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have shown promising results in improving retinal function in various preclinical models of retinal degeneration and clinical studies without any severe side effects. Mesenchymal stem cells (MSCs) were utilized to treat optic neuropathy, RP, DR, and glaucoma with positive clinical outcomes. This review summarizes the preclinical and clinical evidence of stem cell therapy and current limitations in utilizing stem cells for retinal degeneration.Keywords: retinal degeneration, retinal pigment epithelial cells, mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, retinitis pigmentosaSharma AJaganathan BGDove Medical Pressarticleretinal degenerationretinal pigment epithelial cellsmesenchymal stem cellsembryonic stem cellsinduced pluripotent stem cellsretinitis pigmentosadiabetic retinopathyMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 299-306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal degeneration retinal pigment epithelial cells mesenchymal stem cells embryonic stem cells induced pluripotent stem cells retinitis pigmentosa diabetic retinopathy Medicine (General) R5-920
spellingShingle	retinal degeneration retinal pigment epithelial cells mesenchymal stem cells embryonic stem cells induced pluripotent stem cells retinitis pigmentosa diabetic retinopathy Medicine (General) R5-920 Sharma A Jaganathan BG Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
description	Amit Sharma, Bithiah Grace Jaganathan Stem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, IndiaCorrespondence: Bithiah Grace JaganathanStem Cells and Cancer Biology Research Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, IndiaTel +91 361 258 2219Email bithiahgj@iitg.ac.inAbstract: There is a rise in the number of people who have vision loss due to retinal diseases, and conventional therapies for treating retinal degeneration fail to repair and regenerate the damaged retina. Several studies in animal models and human trials have explored the use of stem cells to repair the retinal tissue to improve visual acuity. In addition to the treatment of age-related macular degeneration (AMD) and diabetic retinopathy (DR), stem cell therapies were used to treat genetic diseases such as retinitis pigmentosa (RP) and Stargardt’s disease, characterized by gradual loss of photoreceptor cells in the retina. Transplantation of retinal pigment epithelial (RPE) cells derived from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have shown promising results in improving retinal function in various preclinical models of retinal degeneration and clinical studies without any severe side effects. Mesenchymal stem cells (MSCs) were utilized to treat optic neuropathy, RP, DR, and glaucoma with positive clinical outcomes. This review summarizes the preclinical and clinical evidence of stem cell therapy and current limitations in utilizing stem cells for retinal degeneration.Keywords: retinal degeneration, retinal pigment epithelial cells, mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, retinitis pigmentosa
format	article
author	Sharma A Jaganathan BG
author_facet	Sharma A Jaganathan BG
author_sort	Sharma A
title	Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
title_short	Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
title_full	Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
title_fullStr	Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
title_full_unstemmed	Stem Cell Therapy for Retinal Degeneration: The Evidence to Date
title_sort	stem cell therapy for retinal degeneration: the evidence to date
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c914e0b8b3784680b868f6c64b37cee9
work_keys_str_mv	AT sharmaa stemcelltherapyforretinaldegenerationtheevidencetodate AT jaganathanbg stemcelltherapyforretinaldegenerationtheevidencetodate
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Stem Cell Therapy for Retinal Degeneration: The Evidence to Date

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