Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

ABSTRACT The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to cam...

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Autores principales:	Abdulaziz N. Alagaili, Thomas Briese, Nischay Mishra, Vishal Kapoor, Stephen C. Sameroff, Emmie de Wit, Vincent J. Munster, Lisa E. Hensley, Iyad S. Zalmout, Amit Kapoor, Jonathan H. Epstein, William B. Karesh, Peter Daszak, Osama B. Mohammed, W. Ian Lipkin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c91666ae3b2e4a59987b1a47e617fb64
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spelling	oai:doaj.org-article:c91666ae3b2e4a59987b1a47e617fb642021-11-15T15:45:12ZMiddle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia10.1128/mBio.00884-142150-7511https://doaj.org/article/c91666ae3b2e4a59987b1a47e617fb642014-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00884-14https://doaj.org/toc/2150-7511ABSTRACT The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic and temporal survey of camels in the Kingdom of Saudi Arabia that MERS coronaviruses have been circulating in camels since at least 1992, are distributed countrywide, and can be phylogenetically classified into clades that correlate with outbreaks of the disease among humans. We found no evidence of infection in domestic sheep or domestic goats. IMPORTANCE This study was undertaken to determine the historical and current prevalence of Middle East respiratory syndrome (MERS) coronavirus infection in dromedary camels and other livestock in the Kingdom of Saudi Arabia, where the index case and the majority of cases of MERS have been reported.Abdulaziz N. AlagailiThomas BrieseNischay MishraVishal KapoorStephen C. SameroffEmmie de WitVincent J. MunsterLisa E. HensleyIyad S. ZalmoutAmit KapoorJonathan H. EpsteinWilliam B. KareshPeter DaszakOsama B. MohammedW. Ian LipkinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 2 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Abdulaziz N. Alagaili Thomas Briese Nischay Mishra Vishal Kapoor Stephen C. Sameroff Emmie de Wit Vincent J. Munster Lisa E. Hensley Iyad S. Zalmout Amit Kapoor Jonathan H. Epstein William B. Karesh Peter Daszak Osama B. Mohammed W. Ian Lipkin Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
description	ABSTRACT The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic and temporal survey of camels in the Kingdom of Saudi Arabia that MERS coronaviruses have been circulating in camels since at least 1992, are distributed countrywide, and can be phylogenetically classified into clades that correlate with outbreaks of the disease among humans. We found no evidence of infection in domestic sheep or domestic goats. IMPORTANCE This study was undertaken to determine the historical and current prevalence of Middle East respiratory syndrome (MERS) coronavirus infection in dromedary camels and other livestock in the Kingdom of Saudi Arabia, where the index case and the majority of cases of MERS have been reported.
format	article
author	Abdulaziz N. Alagaili Thomas Briese Nischay Mishra Vishal Kapoor Stephen C. Sameroff Emmie de Wit Vincent J. Munster Lisa E. Hensley Iyad S. Zalmout Amit Kapoor Jonathan H. Epstein William B. Karesh Peter Daszak Osama B. Mohammed W. Ian Lipkin
author_facet	Abdulaziz N. Alagaili Thomas Briese Nischay Mishra Vishal Kapoor Stephen C. Sameroff Emmie de Wit Vincent J. Munster Lisa E. Hensley Iyad S. Zalmout Amit Kapoor Jonathan H. Epstein William B. Karesh Peter Daszak Osama B. Mohammed W. Ian Lipkin
author_sort	Abdulaziz N. Alagaili
title	Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
title_short	Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
title_full	Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
title_fullStr	Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
title_full_unstemmed	Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia
title_sort	middle east respiratory syndrome coronavirus infection in dromedary camels in saudi arabia
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/c91666ae3b2e4a59987b1a47e617fb64
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Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

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