Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics
NF-κB signalling involves the scaffold protein NEMO, which can be bound by the oncoprotein vFLIP to promote cell survival and oncogenic transformation. Here the authors rationally engineer a tertiary protein mimic of NEMO to disrupt the vFLIP-NEMO interaction to induce cell death.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/c91a73658de949548aa1a6962b0fe8cd |
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oai:doaj.org-article:c91a73658de949548aa1a6962b0fe8cd2021-12-02T15:37:07ZModulation of virus-induced NF-κB signaling by NEMO coiled coil mimics10.1038/s41467-020-15576-32041-1723https://doaj.org/article/c91a73658de949548aa1a6962b0fe8cd2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15576-3https://doaj.org/toc/2041-1723NF-κB signalling involves the scaffold protein NEMO, which can be bound by the oncoprotein vFLIP to promote cell survival and oncogenic transformation. Here the authors rationally engineer a tertiary protein mimic of NEMO to disrupt the vFLIP-NEMO interaction to induce cell death.Jouliana SadekMichael G. WuoDavid RooklinArthur HauensteinSeong Ho HongArchana GautamHao WuYingkai ZhangEthel CesarmanParamjit S. AroraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Jouliana Sadek Michael G. Wuo David Rooklin Arthur Hauenstein Seong Ho Hong Archana Gautam Hao Wu Yingkai Zhang Ethel Cesarman Paramjit S. Arora Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics |
| description |
NF-κB signalling involves the scaffold protein NEMO, which can be bound by the oncoprotein vFLIP to promote cell survival and oncogenic transformation. Here the authors rationally engineer a tertiary protein mimic of NEMO to disrupt the vFLIP-NEMO interaction to induce cell death. |
| format |
article |
| author |
Jouliana Sadek Michael G. Wuo David Rooklin Arthur Hauenstein Seong Ho Hong Archana Gautam Hao Wu Yingkai Zhang Ethel Cesarman Paramjit S. Arora |
| author_facet |
Jouliana Sadek Michael G. Wuo David Rooklin Arthur Hauenstein Seong Ho Hong Archana Gautam Hao Wu Yingkai Zhang Ethel Cesarman Paramjit S. Arora |
| author_sort |
Jouliana Sadek |
| title |
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics |
| title_short |
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics |
| title_full |
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics |
| title_fullStr |
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics |
| title_full_unstemmed |
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics |
| title_sort |
modulation of virus-induced nf-κb signaling by nemo coiled coil mimics |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c91a73658de949548aa1a6962b0fe8cd |
| work_keys_str_mv |
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| _version_ |
1718386258321866752 |