Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker

This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first...

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Autores principales:	Anita Ratna Faoziyah, Wahyu Kurniawan
Formato:	article
Lenguaje:	ID
Publicado:	LPPM STIKES Guna Bangsa Yogyakarta 2017
Materias:	mangrove leaf extract solvent variation nano emulsion Medicine R
Acceso en línea:	https://doaj.org/article/c91aa65d3dd54b09b601998679f2fb36
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spelling	oai:doaj.org-article:c91aa65d3dd54b09b601998679f2fb362021-11-12T14:08:14ZPemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker2355-88572407-637610.30590/vol4-no2-p68-74https://doaj.org/article/c91aa65d3dd54b09b601998679f2fb362017-07-01T00:00:00Zhttps://journal.gunabangsa.ac.id/index.php/joh/article/view/100https://doaj.org/toc/2355-8857https://doaj.org/toc/2407-6376This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first phase, mangrove leaves was extracted using various solvent. In the second phase mangrove leaves extract was formulated as nano emulsion as anti-cancer treatment along as an alternative to increase mangrove leaves economic value. Extraction results of mangrove leaves using various solvent such as hexane, ethyl acetate and ethanol show that using ethanol p.a solvent with the young leaves of mangrove giving the highest amount extract as much as 18.24%. Mangrove leaves extract nano emulsion can be prepared using Self-Nano Emulsifying Drug Delivery System (SNEDDS) technique. The SNEDDS technique nano emulsion formulation started with 14 formulas. The best formula from this study was using Tween 80 : PEG 400 : Fish Oil as much as 6 ml: 1 ml: 1 ml dosage ratio. Using the best formula, it was added with 5 mg of mangrove leaves extract. The result test of Drug Loading, calculation of Emulsification Time and Dissolution test show that mangrove leaves extract has the potential to be used as an active substance anti-cancer on nano emulsion manufacturing.Anita Ratna FaoziyahWahyu KurniawanLPPM STIKES Guna Bangsa Yogyakartaarticlemangrove leaf extractsolvent variationnano emulsionMedicineRIDJournal of Health (JOH), Vol 4, Iss 2, Pp 68-74 (2017)
institution	DOAJ
collection	DOAJ
language	ID
topic	mangrove leaf extract solvent variation nano emulsion Medicine R
spellingShingle	mangrove leaf extract solvent variation nano emulsion Medicine R Anita Ratna Faoziyah Wahyu Kurniawan Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker
description	This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first phase, mangrove leaves was extracted using various solvent. In the second phase mangrove leaves extract was formulated as nano emulsion as anti-cancer treatment along as an alternative to increase mangrove leaves economic value. Extraction results of mangrove leaves using various solvent such as hexane, ethyl acetate and ethanol show that using ethanol p.a solvent with the young leaves of mangrove giving the highest amount extract as much as 18.24%. Mangrove leaves extract nano emulsion can be prepared using Self-Nano Emulsifying Drug Delivery System (SNEDDS) technique. The SNEDDS technique nano emulsion formulation started with 14 formulas. The best formula from this study was using Tween 80 : PEG 400 : Fish Oil as much as 6 ml: 1 ml: 1 ml dosage ratio. Using the best formula, it was added with 5 mg of mangrove leaves extract. The result test of Drug Loading, calculation of Emulsification Time and Dissolution test show that mangrove leaves extract has the potential to be used as an active substance anti-cancer on nano emulsion manufacturing.
format	article
author	Anita Ratna Faoziyah Wahyu Kurniawan
author_facet	Anita Ratna Faoziyah Wahyu Kurniawan
author_sort	Anita Ratna Faoziyah
title	Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker
title_short	Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker
title_full	Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker
title_fullStr	Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker
title_full_unstemmed	Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker
title_sort	pemanfaatan ekstrak daun mangrove (rhizophora mucronata sp.) dengan variasi pelarut sebagai bahan aktif sediaan farmasi terapi anti kanker
publisher	LPPM STIKES Guna Bangsa Yogyakarta
publishDate	2017
url	https://doaj.org/article/c91aa65d3dd54b09b601998679f2fb36
work_keys_str_mv	AT anitaratnafaoziyah pemanfaatanekstrakdaunmangroverhizophoramucronataspdenganvariasipelarutsebagaibahanaktifsediaanfarmasiterapiantikanker AT wahyukurniawan pemanfaatanekstrakdaunmangroverhizophoramucronataspdenganvariasipelarutsebagaibahanaktifsediaanfarmasiterapiantikanker
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Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker

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