Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clearance, along with its role in aging related intesti...

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Auteurs principaux:	Imilce A. Rodriguez-Fernandez, Yanyan Qi, Heinrich Jasper
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c91d0dc61d5447c88984735a68a69b99
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spelling	oai:doaj.org-article:c91d0dc61d5447c88984735a68a69b992021-12-02T14:40:19ZLoss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction10.1038/s41467-019-08982-92041-1723https://doaj.org/article/c91d0dc61d5447c88984735a68a69b992019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08982-9https://doaj.org/toc/2041-1723Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clearance, along with its role in aging related intestinal dysfunction.Imilce A. Rodriguez-FernandezYanyan QiHeinrich JasperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Imilce A. Rodriguez-Fernandez Yanyan Qi Heinrich Jasper Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
description	Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clearance, along with its role in aging related intestinal dysfunction.
format	article
author	Imilce A. Rodriguez-Fernandez Yanyan Qi Heinrich Jasper
author_facet	Imilce A. Rodriguez-Fernandez Yanyan Qi Heinrich Jasper
author_sort	Imilce A. Rodriguez-Fernandez
title	Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
title_short	Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
title_full	Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
title_fullStr	Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
title_full_unstemmed	Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
title_sort	loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c91d0dc61d5447c88984735a68a69b99
work_keys_str_mv	AT imilcearodriguezfernandez lossofaproteostaticcheckpointinintestinalstemcellscontributestoagerelatedepithelialdysfunction AT yanyanqi lossofaproteostaticcheckpointinintestinalstemcellscontributestoagerelatedepithelialdysfunction AT heinrichjasper lossofaproteostaticcheckpointinintestinalstemcellscontributestoagerelatedepithelialdysfunction
_version_	1718390324173209600

Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

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