BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice

Introduction Exercise training is a coadjuvant therapy in preventive cardiology, and it delays cardiac dysfunction and exercise intolerance in heart failure (HF). However, the mechanisms underlying muscle function improvement and cardioprotection are poorly understood. In this study, we tested wheth...

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Autores principales:	Zheng Zhang, Beili Wang, Aihua Fei
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	heart failure exercise training ventricular function skeletal muscle bdnf/trkb ampk/pgc1α Medicine R
Acceso en línea:	https://doaj.org/article/c92039caad93411cad2875216371cc2a
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spelling	oai:doaj.org-article:c92039caad93411cad2875216371cc2a2021-12-02T19:15:49ZBDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice1734-19221896-915110.5114/aoms.2018.81037https://doaj.org/article/c92039caad93411cad2875216371cc2a2018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/BDNF-contributes-to-the-skeletal-muscle-anti-atrophic-effect-of-exercise-training,81172,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Exercise training is a coadjuvant therapy in preventive cardiology, and it delays cardiac dysfunction and exercise intolerance in heart failure (HF). However, the mechanisms underlying muscle function improvement and cardioprotection are poorly understood. In this study, we tested whether exercise training would counteract skeletal muscle atrophy via activation of the BDNF pathway in myocardial infarction (MI)-induced HF mice. Material and methods A cohort of male Sham-operated and MI mice were assigned into 8-week moderate exercise training, and untrained counterparters were used as control. Exercise capacity, plasma norepinephrine (NE) level, heart rate (HR), fractional shortening (FS) and ejection fraction (EF) were measured. The protein expression of BDNF, p-TrkB, p-AMPK and PGC1α were analyzed by Western blot. Results Compared with the Sham-operated mice, MI mice displayed reduced total distance run and elevated plasma NE level (both p < 0.05). Exercise training significantly improved distance run and plasma NE levels in HF mice (both p < 0.05). Significantly increased HR, decreased FS and EF were observed in the MI group as compared to the Sham-operated group, and exercise training prevent the hemodynamic status and systolic dysfunction in MI mice (all p < 0.05). The expression of BDNF, p-TrkB, p-AMPK and PGC1α were significantly decreased in the skeletal muscle from MI compared to Sham-operated mice, which were significantly increased by exercise training (all p < 0.05). In addition, BDNF siRNA markedly decreased the protein level of p-AMPK and PGC1α in C2C12 myoblasts. Conclusions Taken together, our data provide evidence for exercise training may counteract HF-induced muscle atrophy through induced activation of BDNF pathway.Zheng ZhangBeili WangAihua FeiTermedia Publishing Housearticleheart failureexercise trainingventricular functionskeletal muscleventricular functionbdnf/trkbampk/pgc1αMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 214-222 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart failure exercise training ventricular function skeletal muscle ventricular function bdnf/trkb ampk/pgc1α Medicine R
spellingShingle	heart failure exercise training ventricular function skeletal muscle ventricular function bdnf/trkb ampk/pgc1α Medicine R Zheng Zhang Beili Wang Aihua Fei BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
description	Introduction Exercise training is a coadjuvant therapy in preventive cardiology, and it delays cardiac dysfunction and exercise intolerance in heart failure (HF). However, the mechanisms underlying muscle function improvement and cardioprotection are poorly understood. In this study, we tested whether exercise training would counteract skeletal muscle atrophy via activation of the BDNF pathway in myocardial infarction (MI)-induced HF mice. Material and methods A cohort of male Sham-operated and MI mice were assigned into 8-week moderate exercise training, and untrained counterparters were used as control. Exercise capacity, plasma norepinephrine (NE) level, heart rate (HR), fractional shortening (FS) and ejection fraction (EF) were measured. The protein expression of BDNF, p-TrkB, p-AMPK and PGC1α were analyzed by Western blot. Results Compared with the Sham-operated mice, MI mice displayed reduced total distance run and elevated plasma NE level (both p < 0.05). Exercise training significantly improved distance run and plasma NE levels in HF mice (both p < 0.05). Significantly increased HR, decreased FS and EF were observed in the MI group as compared to the Sham-operated group, and exercise training prevent the hemodynamic status and systolic dysfunction in MI mice (all p < 0.05). The expression of BDNF, p-TrkB, p-AMPK and PGC1α were significantly decreased in the skeletal muscle from MI compared to Sham-operated mice, which were significantly increased by exercise training (all p < 0.05). In addition, BDNF siRNA markedly decreased the protein level of p-AMPK and PGC1α in C2C12 myoblasts. Conclusions Taken together, our data provide evidence for exercise training may counteract HF-induced muscle atrophy through induced activation of BDNF pathway.
format	article
author	Zheng Zhang Beili Wang Aihua Fei
author_facet	Zheng Zhang Beili Wang Aihua Fei
author_sort	Zheng Zhang
title	BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
title_short	BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
title_full	BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
title_fullStr	BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
title_full_unstemmed	BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
title_sort	bdnf contributes to the skeletal muscle anti-atrophic effect of exercise training through ampk-pgc1α signaling in heart failure mice
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/c92039caad93411cad2875216371cc2a
work_keys_str_mv	AT zhengzhang bdnfcontributestotheskeletalmuscleantiatrophiceffectofexercisetrainingthroughampkpgc1asignalinginheartfailuremice AT beiliwang bdnfcontributestotheskeletalmuscleantiatrophiceffectofexercisetrainingthroughampkpgc1asignalinginheartfailuremice AT aihuafei bdnfcontributestotheskeletalmuscleantiatrophiceffectofexercisetrainingthroughampkpgc1asignalinginheartfailuremice
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BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice

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