HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-...
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2020
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oai:doaj.org-article:c9223cd55c18449db9d005eb65c4887e2021-12-02T17:08:46ZHIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice10.1038/s41467-020-17873-32041-1723https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17873-3https://doaj.org/toc/2041-1723Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-2α deletion has only a moderate effect.Rouven HoefflinSabine HarlanderSilvia SchäferPatrick MetzgerFengshen KuoDésirée SchönenbergerMojca AdlesicAsin PeighambariPhilipp SeidelChia-yi ChenMiguel Consenza-ContrerasAndreas JudBernd LahrmannNiels GrabeDanijela HeideFranziska M. UhlTimothy A. ChanJustus DuysterRobert ZeiserChristoph SchellMathias HeikenwalderOliver SchillingA. Ari HakimiMelanie BoerriesIan J. FrewNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020) |
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DOAJ |
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DOAJ |
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| topic |
Science Q |
| spellingShingle |
Science Q Rouven Hoefflin Sabine Harlander Silvia Schäfer Patrick Metzger Fengshen Kuo Désirée Schönenberger Mojca Adlesic Asin Peighambari Philipp Seidel Chia-yi Chen Miguel Consenza-Contreras Andreas Jud Bernd Lahrmann Niels Grabe Danijela Heide Franziska M. Uhl Timothy A. Chan Justus Duyster Robert Zeiser Christoph Schell Mathias Heikenwalder Oliver Schilling A. Ari Hakimi Melanie Boerries Ian J. Frew HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| description |
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-2α deletion has only a moderate effect. |
| format |
article |
| author |
Rouven Hoefflin Sabine Harlander Silvia Schäfer Patrick Metzger Fengshen Kuo Désirée Schönenberger Mojca Adlesic Asin Peighambari Philipp Seidel Chia-yi Chen Miguel Consenza-Contreras Andreas Jud Bernd Lahrmann Niels Grabe Danijela Heide Franziska M. Uhl Timothy A. Chan Justus Duyster Robert Zeiser Christoph Schell Mathias Heikenwalder Oliver Schilling A. Ari Hakimi Melanie Boerries Ian J. Frew |
| author_facet |
Rouven Hoefflin Sabine Harlander Silvia Schäfer Patrick Metzger Fengshen Kuo Désirée Schönenberger Mojca Adlesic Asin Peighambari Philipp Seidel Chia-yi Chen Miguel Consenza-Contreras Andreas Jud Bernd Lahrmann Niels Grabe Danijela Heide Franziska M. Uhl Timothy A. Chan Justus Duyster Robert Zeiser Christoph Schell Mathias Heikenwalder Oliver Schilling A. Ari Hakimi Melanie Boerries Ian J. Frew |
| author_sort |
Rouven Hoefflin |
| title |
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| title_short |
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| title_full |
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| title_fullStr |
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| title_full_unstemmed |
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| title_sort |
hif-1α and hif-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c9223cd55c18449db9d005eb65c4887e |
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