E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair

E2F1, which localises to DNA double-strand breaks (DSBs) to promote repair, is acetylated in response to DNA damage but the role this plays in DNA repair is unknown. Here the authors show that E2F1 acetylation creates a binding motif for the bromodomains of the p300/KAT3B and CBP/KAT3A acetyltransfe...

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Autores principales:	Swarnalatha Manickavinayaham, Renier Vélez-Cruz, Anup K. Biswas, Ella Bedford, Brianna J. Klein, Tatiana G. Kutateladze, Bin Liu, Mark T. Bedford, David G. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c922be47af0c487c9f56067db1a6901f
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spelling	oai:doaj.org-article:c922be47af0c487c9f56067db1a6901f2021-12-02T16:57:06ZE2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair10.1038/s41467-019-12861-82041-1723https://doaj.org/article/c922be47af0c487c9f56067db1a6901f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12861-8https://doaj.org/toc/2041-1723E2F1, which localises to DNA double-strand breaks (DSBs) to promote repair, is acetylated in response to DNA damage but the role this plays in DNA repair is unknown. Here the authors show that E2F1 acetylation creates a binding motif for the bromodomains of the p300/KAT3B and CBP/KAT3A acetyltransferases, which is required for recruitment of p300 and CBP to DSBs, to facilate repair.Swarnalatha ManickavinayahamRenier Vélez-CruzAnup K. BiswasElla BedfordBrianna J. KleinTatiana G. KutateladzeBin LiuMark T. BedfordDavid G. JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swarnalatha Manickavinayaham Renier Vélez-Cruz Anup K. Biswas Ella Bedford Brianna J. Klein Tatiana G. Kutateladze Bin Liu Mark T. Bedford David G. Johnson E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair
description	E2F1, which localises to DNA double-strand breaks (DSBs) to promote repair, is acetylated in response to DNA damage but the role this plays in DNA repair is unknown. Here the authors show that E2F1 acetylation creates a binding motif for the bromodomains of the p300/KAT3B and CBP/KAT3A acetyltransferases, which is required for recruitment of p300 and CBP to DSBs, to facilate repair.
format	article
author	Swarnalatha Manickavinayaham Renier Vélez-Cruz Anup K. Biswas Ella Bedford Brianna J. Klein Tatiana G. Kutateladze Bin Liu Mark T. Bedford David G. Johnson
author_facet	Swarnalatha Manickavinayaham Renier Vélez-Cruz Anup K. Biswas Ella Bedford Brianna J. Klein Tatiana G. Kutateladze Bin Liu Mark T. Bedford David G. Johnson
author_sort	Swarnalatha Manickavinayaham
title	E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair
title_short	E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair
title_full	E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair
title_fullStr	E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair
title_full_unstemmed	E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair
title_sort	e2f1 acetylation directs p300/cbp-mediated histone acetylation at dna double-strand breaks to facilitate repair
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c922be47af0c487c9f56067db1a6901f
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E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair

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