Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.

Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sl...

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Autores principales:	Tetsuya Ishizawa, Naohiko Makino, Yasuharu Kakizaki, Akiko Matsuda, Yoshihide Toyokawa, Shun Ooyama, Masaru Tanaka, Yoshiyuki Ueno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9230a85289045588e1119057859c658
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spelling	oai:doaj.org-article:c9230a85289045588e1119057859c6582021-12-02T20:14:11ZBiosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.1932-620310.1371/journal.pone.0257828https://doaj.org/article/c9230a85289045588e1119057859c6582021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257828https://doaj.org/toc/1932-6203Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sludge resistance and examine its biosafety in vivo. Using endoscopic retrograde cholangiopancreatography, we placed the PMEA-CSEMS into six normal porcine bile ducts and conventional CSEMS into three normal porcine bile ducts. We performed serological examination and undecalcified histological analysis at 1, 3, and 6 months during follow-up. In the bile ducts with PMEA-CSEMS or conventional CSEMS, we observed no increase in liver enzyme or inflammatory marker levels in the serological investigations and mild fibrosis but no inflammatory response in the histopathological analyses. Thus, we demonstrated the biosafety of PMEA-CSEMS in vivo.Tetsuya IshizawaNaohiko MakinoYasuharu KakizakiAkiko MatsudaYoshihide ToyokawaShun OoyamaMasaru TanakaYoshiyuki UenoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257828 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tetsuya Ishizawa Naohiko Makino Yasuharu Kakizaki Akiko Matsuda Yoshihide Toyokawa Shun Ooyama Masaru Tanaka Yoshiyuki Ueno Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
description	Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sludge resistance and examine its biosafety in vivo. Using endoscopic retrograde cholangiopancreatography, we placed the PMEA-CSEMS into six normal porcine bile ducts and conventional CSEMS into three normal porcine bile ducts. We performed serological examination and undecalcified histological analysis at 1, 3, and 6 months during follow-up. In the bile ducts with PMEA-CSEMS or conventional CSEMS, we observed no increase in liver enzyme or inflammatory marker levels in the serological investigations and mild fibrosis but no inflammatory response in the histopathological analyses. Thus, we demonstrated the biosafety of PMEA-CSEMS in vivo.
format	article
author	Tetsuya Ishizawa Naohiko Makino Yasuharu Kakizaki Akiko Matsuda Yoshihide Toyokawa Shun Ooyama Masaru Tanaka Yoshiyuki Ueno
author_facet	Tetsuya Ishizawa Naohiko Makino Yasuharu Kakizaki Akiko Matsuda Yoshihide Toyokawa Shun Ooyama Masaru Tanaka Yoshiyuki Ueno
author_sort	Tetsuya Ishizawa
title	Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
title_short	Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
title_full	Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
title_fullStr	Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
title_full_unstemmed	Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
title_sort	biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c9230a85289045588e1119057859c658
work_keys_str_mv	AT tetsuyaishizawa biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT naohikomakino biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT yasuharukakizaki biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT akikomatsuda biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT yoshihidetoyokawa biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT shunooyama biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT masarutanaka biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo AT yoshiyukiueno biosafetyofanovelcoveredselfexpandablemetalstentcoatedwithpoly2methoxyethylacrylateinvivo
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Biosafety of a novel covered self-expandable metal stent coated with poly(2-methoxyethyl acrylate) in vivo.

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