The impact of chromosomal fusions on 3D genome folding and recombination in the germ line

The impact of chromosomal fusions on 3D genome folding and recombination in the germ line

How mammalian genomes are packaged and the heritability of structural variations in genome folding is incomplete. Here, the authors investigate the impact of chromosomal fusions on three-dimensional genome topology and meiotic recombination, highlighting the implications of large-scale genome reorga...

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Autores principales: Covadonga Vara, Andreu Paytuví-Gallart, Yasmina Cuartero, Lucía Álvarez-González, Laia Marín-Gual, Francisca Garcia, Beatriu Florit-Sabater, Laia Capilla, Rosa Ana Sanchéz-Guillén, Zaida Sarrate, Riccardo Aiese Cigliano, Walter Sanseverino, Jeremy B. Searle, Jacint Ventura, Marc A. Marti-Renom, François Le Dily, Aurora Ruiz-Herrera
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c92363c329ee48cd9f4564a18ec00bb4
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spelling oai:doaj.org-article:c92363c329ee48cd9f4564a18ec00bb42021-12-02T16:51:25ZThe impact of chromosomal fusions on 3D genome folding and recombination in the germ line10.1038/s41467-021-23270-12041-1723https://doaj.org/article/c92363c329ee48cd9f4564a18ec00bb42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23270-1https://doaj.org/toc/2041-1723How mammalian genomes are packaged and the heritability of structural variations in genome folding is incomplete. Here, the authors investigate the impact of chromosomal fusions on three-dimensional genome topology and meiotic recombination, highlighting the implications of large-scale genome reorganizations on genome function, evolution, and fertility.Covadonga VaraAndreu Paytuví-GallartYasmina CuarteroLucía Álvarez-GonzálezLaia Marín-GualFrancisca GarciaBeatriu Florit-SabaterLaia CapillaRosa Ana Sanchéz-GuillénZaida SarrateRiccardo Aiese CiglianoWalter SanseverinoJeremy B. SearleJacint VenturaMarc A. Marti-RenomFrançois Le DilyAurora Ruiz-HerreraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Covadonga Vara
Andreu Paytuví-Gallart
Yasmina Cuartero
Lucía Álvarez-González
Laia Marín-Gual
Francisca Garcia
Beatriu Florit-Sabater
Laia Capilla
Rosa Ana Sanchéz-Guillén
Zaida Sarrate
Riccardo Aiese Cigliano
Walter Sanseverino
Jeremy B. Searle
Jacint Ventura
Marc A. Marti-Renom
François Le Dily
Aurora Ruiz-Herrera
The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
description How mammalian genomes are packaged and the heritability of structural variations in genome folding is incomplete. Here, the authors investigate the impact of chromosomal fusions on three-dimensional genome topology and meiotic recombination, highlighting the implications of large-scale genome reorganizations on genome function, evolution, and fertility.
format article
author Covadonga Vara
Andreu Paytuví-Gallart
Yasmina Cuartero
Lucía Álvarez-González
Laia Marín-Gual
Francisca Garcia
Beatriu Florit-Sabater
Laia Capilla
Rosa Ana Sanchéz-Guillén
Zaida Sarrate
Riccardo Aiese Cigliano
Walter Sanseverino
Jeremy B. Searle
Jacint Ventura
Marc A. Marti-Renom
François Le Dily
Aurora Ruiz-Herrera
author_facet Covadonga Vara
Andreu Paytuví-Gallart
Yasmina Cuartero
Lucía Álvarez-González
Laia Marín-Gual
Francisca Garcia
Beatriu Florit-Sabater
Laia Capilla
Rosa Ana Sanchéz-Guillén
Zaida Sarrate
Riccardo Aiese Cigliano
Walter Sanseverino
Jeremy B. Searle
Jacint Ventura
Marc A. Marti-Renom
François Le Dily
Aurora Ruiz-Herrera
author_sort Covadonga Vara
title The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
title_short The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
title_full The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
title_fullStr The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
title_full_unstemmed The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
title_sort impact of chromosomal fusions on 3d genome folding and recombination in the germ line
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c92363c329ee48cd9f4564a18ec00bb4
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