Clusterin and Psoriasis; What is the Relation?

Background: Atherosclerotic infarction accounts for a sizable proportion of cerebral infarcts whether occurs from extracranial or intracranial atherosclerotic disease. Despite recent studies on stroke risk factors; it is still unclear whether or not single risk factor specifically affect extracrania...

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Autores principales:	Osama Hashem, Zakaria Obaid, Heshm Abd Alsamee, Fatma Youssef
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	psoriasis clusterin psoriasis area severity index keratinocyte apolipoprotein j Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c92b7413f2544e8aab509cf802663d40
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spelling	oai:doaj.org-article:c92b7413f2544e8aab509cf802663d402021-12-02T10:38:27ZClusterin and Psoriasis; What is the Relation?2636-41742682-378010.21608/ijma.2019.12703.1005https://doaj.org/article/c92b7413f2544e8aab509cf802663d402020-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_50273_fc795ad88fc61b2d27079fd878d53f12.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Atherosclerotic infarction accounts for a sizable proportion of cerebral infarcts whether occurs from extracranial or intracranial atherosclerotic disease. Despite recent studies on stroke risk factors; it is still unclear whether or not single risk factor specifically affect extracranial or intracranial arteries in stroke patients. Aim of the work: To determine the difference between intracranial and extracranial steno-occlusive atherosclerosis and its correlation with risk factors of acute ischemic stroke using Magnetic Resonance Angiogram (MRA) and/or Computed Tomography Angiography (CTA) with Duplex. Patients and methods: All cases diagnosed as acute ischemic stroke were subjected to detailed history, full neurological examination, routine laboratory tests, extracranial vessels assessed by duplex, intracranial vessels assessed by MRA and/or CTA. Results: 61 patients included in the study (38 males and 23 females), with mean age (64.5 ± 11.4). Extracranial stenosis was (57 patients, 93.4%), while intracranial stenosis was (49 patients, 80.3%). But the intracranial significant stenosis was (45 patients, 73.77%), while the extracranial significant stenosis (26 patients, 42.62%). Hypertension (72.1%), obesity (62.3%), diabetes (57.4%), dyslipidemia (54.1%) and smoking (39.3%), were risk factors equally affecting the extracranial and the intracranial systems in the same descending order. There was a higher prevalence of hypertension among patients with intracranial significant stenosis showing a significant P-value of 0.048. Conclusion: Extracranial stenosis was more common than the intracranial stenosis, but the intracranial significant stenosis is more prevalent than the extracranial. Hypertension is a significant risk factor for intracranial significant stenosisOsama HashemZakaria ObaidHeshm Abd AlsameeFatma YoussefAl-Azhar University, Faculty of Medicine (Damietta)articlepsoriasisclusterinpsoriasis area severity indexkeratinocyteapolipoprotein jMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 1, Pp 152-156 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis clusterin psoriasis area severity index keratinocyte apolipoprotein j Medicine (General) R5-920
spellingShingle	psoriasis clusterin psoriasis area severity index keratinocyte apolipoprotein j Medicine (General) R5-920 Osama Hashem Zakaria Obaid Heshm Abd Alsamee Fatma Youssef Clusterin and Psoriasis; What is the Relation?
description	Background: Atherosclerotic infarction accounts for a sizable proportion of cerebral infarcts whether occurs from extracranial or intracranial atherosclerotic disease. Despite recent studies on stroke risk factors; it is still unclear whether or not single risk factor specifically affect extracranial or intracranial arteries in stroke patients. Aim of the work: To determine the difference between intracranial and extracranial steno-occlusive atherosclerosis and its correlation with risk factors of acute ischemic stroke using Magnetic Resonance Angiogram (MRA) and/or Computed Tomography Angiography (CTA) with Duplex. Patients and methods: All cases diagnosed as acute ischemic stroke were subjected to detailed history, full neurological examination, routine laboratory tests, extracranial vessels assessed by duplex, intracranial vessels assessed by MRA and/or CTA. Results: 61 patients included in the study (38 males and 23 females), with mean age (64.5 ± 11.4). Extracranial stenosis was (57 patients, 93.4%), while intracranial stenosis was (49 patients, 80.3%). But the intracranial significant stenosis was (45 patients, 73.77%), while the extracranial significant stenosis (26 patients, 42.62%). Hypertension (72.1%), obesity (62.3%), diabetes (57.4%), dyslipidemia (54.1%) and smoking (39.3%), were risk factors equally affecting the extracranial and the intracranial systems in the same descending order. There was a higher prevalence of hypertension among patients with intracranial significant stenosis showing a significant P-value of 0.048. Conclusion: Extracranial stenosis was more common than the intracranial stenosis, but the intracranial significant stenosis is more prevalent than the extracranial. Hypertension is a significant risk factor for intracranial significant stenosis
format	article
author	Osama Hashem Zakaria Obaid Heshm Abd Alsamee Fatma Youssef
author_facet	Osama Hashem Zakaria Obaid Heshm Abd Alsamee Fatma Youssef
author_sort	Osama Hashem
title	Clusterin and Psoriasis; What is the Relation?
title_short	Clusterin and Psoriasis; What is the Relation?
title_full	Clusterin and Psoriasis; What is the Relation?
title_fullStr	Clusterin and Psoriasis; What is the Relation?
title_full_unstemmed	Clusterin and Psoriasis; What is the Relation?
title_sort	clusterin and psoriasis; what is the relation?
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/c92b7413f2544e8aab509cf802663d40
work_keys_str_mv	AT osamahashem clusterinandpsoriasiswhatistherelation AT zakariaobaid clusterinandpsoriasiswhatistherelation AT heshmabdalsamee clusterinandpsoriasiswhatistherelation AT fatmayoussef clusterinandpsoriasiswhatistherelation
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Clusterin and Psoriasis; What is the Relation?

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