UBL3 modification influences protein sorting to small extracellular vesicles

Exosomes mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs but the mechanisms of protein sorting to exosomes are poorly understood. Here, the authors uncover that ubiquitin-like 3 (UBL3) regulates protein sorting to exosomes by acting as a posttranslational modification.

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Autores principales:	Hiroshi Ageta, Natsumi Ageta-Ishihara, Keisuke Hitachi, Ozge Karayel, Takanori Onouchi, Hisateru Yamaguchi, Tomoaki Kahyo, Ken Hatanaka, Koji Ikegami, Yusuke Yoshioka, Kenji Nakamura, Nobuyoshi Kosaka, Masashi Nakatani, Akiyoshi Uezumi, Tomihiko Ide, Yutaka Tsutsumi, Haruhiko Sugimura, Makoto Kinoshita, Takahiro Ochiya, Matthias Mann, Mitsutoshi Setou, Kunihiro Tsuchida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c92e3a81f2284cbda20dffe286df8d8c
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spelling	oai:doaj.org-article:c92e3a81f2284cbda20dffe286df8d8c2021-12-02T15:34:29ZUBL3 modification influences protein sorting to small extracellular vesicles10.1038/s41467-018-06197-y2041-1723https://doaj.org/article/c92e3a81f2284cbda20dffe286df8d8c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06197-yhttps://doaj.org/toc/2041-1723Exosomes mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs but the mechanisms of protein sorting to exosomes are poorly understood. Here, the authors uncover that ubiquitin-like 3 (UBL3) regulates protein sorting to exosomes by acting as a posttranslational modification.Hiroshi AgetaNatsumi Ageta-IshiharaKeisuke HitachiOzge KarayelTakanori OnouchiHisateru YamaguchiTomoaki KahyoKen HatanakaKoji IkegamiYusuke YoshiokaKenji NakamuraNobuyoshi KosakaMasashi NakataniAkiyoshi UezumiTomihiko IdeYutaka TsutsumiHaruhiko SugimuraMakoto KinoshitaTakahiro OchiyaMatthias MannMitsutoshi SetouKunihiro TsuchidaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroshi Ageta Natsumi Ageta-Ishihara Keisuke Hitachi Ozge Karayel Takanori Onouchi Hisateru Yamaguchi Tomoaki Kahyo Ken Hatanaka Koji Ikegami Yusuke Yoshioka Kenji Nakamura Nobuyoshi Kosaka Masashi Nakatani Akiyoshi Uezumi Tomihiko Ide Yutaka Tsutsumi Haruhiko Sugimura Makoto Kinoshita Takahiro Ochiya Matthias Mann Mitsutoshi Setou Kunihiro Tsuchida UBL3 modification influences protein sorting to small extracellular vesicles
description	Exosomes mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs but the mechanisms of protein sorting to exosomes are poorly understood. Here, the authors uncover that ubiquitin-like 3 (UBL3) regulates protein sorting to exosomes by acting as a posttranslational modification.
format	article
author	Hiroshi Ageta Natsumi Ageta-Ishihara Keisuke Hitachi Ozge Karayel Takanori Onouchi Hisateru Yamaguchi Tomoaki Kahyo Ken Hatanaka Koji Ikegami Yusuke Yoshioka Kenji Nakamura Nobuyoshi Kosaka Masashi Nakatani Akiyoshi Uezumi Tomihiko Ide Yutaka Tsutsumi Haruhiko Sugimura Makoto Kinoshita Takahiro Ochiya Matthias Mann Mitsutoshi Setou Kunihiro Tsuchida
author_facet	Hiroshi Ageta Natsumi Ageta-Ishihara Keisuke Hitachi Ozge Karayel Takanori Onouchi Hisateru Yamaguchi Tomoaki Kahyo Ken Hatanaka Koji Ikegami Yusuke Yoshioka Kenji Nakamura Nobuyoshi Kosaka Masashi Nakatani Akiyoshi Uezumi Tomihiko Ide Yutaka Tsutsumi Haruhiko Sugimura Makoto Kinoshita Takahiro Ochiya Matthias Mann Mitsutoshi Setou Kunihiro Tsuchida
author_sort	Hiroshi Ageta
title	UBL3 modification influences protein sorting to small extracellular vesicles
title_short	UBL3 modification influences protein sorting to small extracellular vesicles
title_full	UBL3 modification influences protein sorting to small extracellular vesicles
title_fullStr	UBL3 modification influences protein sorting to small extracellular vesicles
title_full_unstemmed	UBL3 modification influences protein sorting to small extracellular vesicles
title_sort	ubl3 modification influences protein sorting to small extracellular vesicles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c92e3a81f2284cbda20dffe286df8d8c
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UBL3 modification influences protein sorting to small extracellular vesicles

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