Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades

Candida albicans and Candida glabrata are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obta...

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Autores principales:	Judit Szarvas, Ana Rita Rebelo, Valeria Bortolaia, Pimlapas Leekitcharoenphon, Dennis Schrøder Hansen, Hans Linde Nielsen, Niels Nørskov-Lauritsen, Michael Kemp, Bent Løwe Røder, Niels Frimodt-Møller, Turid Snekloth Søndergaard, John Eugenio Coia, Claus Østergaard, Henrik Westh, Frank Møller Aarestrup
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	whole-genome sequencing fungal infection antifungal susceptibility phylogenetics Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c92eb91194e9496ca45325e25b7a6b37
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spelling	oai:doaj.org-article:c92eb91194e9496ca45325e25b7a6b372021-11-25T18:06:13ZDanish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades10.3390/jof71109622309-608Xhttps://doaj.org/article/c92eb91194e9496ca45325e25b7a6b372021-11-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/962https://doaj.org/toc/2309-608X<i>Candida albicans</i> and <i>Candida glabrata</i> are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the <i>Candida</i> population in the country. The majority of the 30 <i>C. albicans</i> isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight <i>C. glabrata</i> isolates were predicted to be prevalent subtypes. Antifungal susceptibility testing proved all <i>C. albicans</i> isolates to be susceptible to both azoles and echinocandins. Two <i>C. glabrata</i> isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species.Judit SzarvasAna Rita RebeloValeria BortolaiaPimlapas LeekitcharoenphonDennis Schrøder HansenHans Linde NielsenNiels Nørskov-LauritsenMichael KempBent Løwe RøderNiels Frimodt-MøllerTurid Snekloth SøndergaardJohn Eugenio CoiaClaus ØstergaardHenrik WesthFrank Møller AarestrupMDPI AGarticlewhole-genome sequencingfungal infectionantifungal susceptibilityphylogeneticsBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 962, p 962 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	whole-genome sequencing fungal infection antifungal susceptibility phylogenetics Biology (General) QH301-705.5
spellingShingle	whole-genome sequencing fungal infection antifungal susceptibility phylogenetics Biology (General) QH301-705.5 Judit Szarvas Ana Rita Rebelo Valeria Bortolaia Pimlapas Leekitcharoenphon Dennis Schrøder Hansen Hans Linde Nielsen Niels Nørskov-Lauritsen Michael Kemp Bent Løwe Røder Niels Frimodt-Møller Turid Snekloth Søndergaard John Eugenio Coia Claus Østergaard Henrik Westh Frank Møller Aarestrup Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades
description	<i>Candida albicans</i> and <i>Candida glabrata</i> are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the <i>Candida</i> population in the country. The majority of the 30 <i>C. albicans</i> isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight <i>C. glabrata</i> isolates were predicted to be prevalent subtypes. Antifungal susceptibility testing proved all <i>C. albicans</i> isolates to be susceptible to both azoles and echinocandins. Two <i>C. glabrata</i> isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species.
format	article
author	Judit Szarvas Ana Rita Rebelo Valeria Bortolaia Pimlapas Leekitcharoenphon Dennis Schrøder Hansen Hans Linde Nielsen Niels Nørskov-Lauritsen Michael Kemp Bent Løwe Røder Niels Frimodt-Møller Turid Snekloth Søndergaard John Eugenio Coia Claus Østergaard Henrik Westh Frank Møller Aarestrup
author_facet	Judit Szarvas Ana Rita Rebelo Valeria Bortolaia Pimlapas Leekitcharoenphon Dennis Schrøder Hansen Hans Linde Nielsen Niels Nørskov-Lauritsen Michael Kemp Bent Løwe Røder Niels Frimodt-Møller Turid Snekloth Søndergaard John Eugenio Coia Claus Østergaard Henrik Westh Frank Møller Aarestrup
author_sort	Judit Szarvas
title	Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades
title_short	Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades
title_full	Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades
title_fullStr	Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades
title_full_unstemmed	Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades
title_sort	danish whole-genome-sequenced <i>candida albicans</i> and <i>candida glabrata</i> samples fit into globally prevalent clades
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c92eb91194e9496ca45325e25b7a6b37
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Danish Whole-Genome-Sequenced <i>Candida albicans</i> and <i>Candida glabrata</i> Samples Fit into Globally Prevalent Clades

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