Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.

Stochastic processes and imprinting, along with genetic factors, lead to monoallelic or allele-biased gene expression. Stochastic monoallelic expression fine-tunes information processing in immune cells and the olfactory system, and imprinting plays an important role in development. Recent studies s...

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Autores principales:	Mingyan Lin, Anastasia Hrabovsky, Erika Pedrosa, Tao Wang, Deyou Zheng, Herbert M Lachman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c92ec5198adf45c79f02acb7650b35df
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spelling	oai:doaj.org-article:c92ec5198adf45c79f02acb7650b35df2021-11-18T07:07:01ZAllele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.1932-620310.1371/journal.pone.0044017https://doaj.org/article/c92ec5198adf45c79f02acb7650b35df2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952857/?tool=EBIhttps://doaj.org/toc/1932-6203Stochastic processes and imprinting, along with genetic factors, lead to monoallelic or allele-biased gene expression. Stochastic monoallelic expression fine-tunes information processing in immune cells and the olfactory system, and imprinting plays an important role in development. Recent studies suggest that both stochastic events and imprinting may be more widespread than previously considered. We are interested in allele-biased gene expression occurring in the brain because parent-of-origin effects suggestive of imprinting appear to play a role in the transmission of schizophrenia (SZ) and autism spectrum disorders (ASD) in some families. In addition, allele-biased expression could help explain monozygotic (MZ) twin discordance and reduced penetrance. The ability to study allele-biased expression in human neurons has been transformed with the advent of induced pluripotent stem cell (iPSC) technology and next generation sequencing. Using transcriptome sequencing (RNA-Seq) we identified 801 genes in differentiating neurons that were expressed in an allele-biased manner. These included a number of putative SZ and ASD candidates, such as A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1. Overall, there was a modest enrichment for SZ and ASD candidate genes among those that showed evidence for allele-biased expression (chi-square, p = 0.02). In addition to helping explain MZ twin discordance and reduced penetrance, the capacity to group many candidate genes affecting a variety of molecular and cellular pathways under a common regulatory process - allele-biased expression - could have therapeutic implications.Mingyan LinAnastasia HrabovskyErika PedrosaTao WangDeyou ZhengHerbert M LachmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e44017 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mingyan Lin Anastasia Hrabovsky Erika Pedrosa Tao Wang Deyou Zheng Herbert M Lachman Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
description	Stochastic processes and imprinting, along with genetic factors, lead to monoallelic or allele-biased gene expression. Stochastic monoallelic expression fine-tunes information processing in immune cells and the olfactory system, and imprinting plays an important role in development. Recent studies suggest that both stochastic events and imprinting may be more widespread than previously considered. We are interested in allele-biased gene expression occurring in the brain because parent-of-origin effects suggestive of imprinting appear to play a role in the transmission of schizophrenia (SZ) and autism spectrum disorders (ASD) in some families. In addition, allele-biased expression could help explain monozygotic (MZ) twin discordance and reduced penetrance. The ability to study allele-biased expression in human neurons has been transformed with the advent of induced pluripotent stem cell (iPSC) technology and next generation sequencing. Using transcriptome sequencing (RNA-Seq) we identified 801 genes in differentiating neurons that were expressed in an allele-biased manner. These included a number of putative SZ and ASD candidates, such as A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1. Overall, there was a modest enrichment for SZ and ASD candidate genes among those that showed evidence for allele-biased expression (chi-square, p = 0.02). In addition to helping explain MZ twin discordance and reduced penetrance, the capacity to group many candidate genes affecting a variety of molecular and cellular pathways under a common regulatory process - allele-biased expression - could have therapeutic implications.
format	article
author	Mingyan Lin Anastasia Hrabovsky Erika Pedrosa Tao Wang Deyou Zheng Herbert M Lachman
author_facet	Mingyan Lin Anastasia Hrabovsky Erika Pedrosa Tao Wang Deyou Zheng Herbert M Lachman
author_sort	Mingyan Lin
title	Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
title_short	Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
title_full	Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
title_fullStr	Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
title_full_unstemmed	Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
title_sort	allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c92ec5198adf45c79f02acb7650b35df
work_keys_str_mv	AT mingyanlin allelebiasedexpressionindifferentiatinghumanneuronsimplicationsforneuropsychiatricdisorders AT anastasiahrabovsky allelebiasedexpressionindifferentiatinghumanneuronsimplicationsforneuropsychiatricdisorders AT erikapedrosa allelebiasedexpressionindifferentiatinghumanneuronsimplicationsforneuropsychiatricdisorders AT taowang allelebiasedexpressionindifferentiatinghumanneuronsimplicationsforneuropsychiatricdisorders AT deyouzheng allelebiasedexpressionindifferentiatinghumanneuronsimplicationsforneuropsychiatricdisorders AT herbertmlachman allelebiasedexpressionindifferentiatinghumanneuronsimplicationsforneuropsychiatricdisorders
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Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.

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