Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.

In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do no...

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Autores principales:	Evgeniya A Vaskova, Elena V Dementyeva, Alexander I Shevchenko, Sophia V Pavlova, Elena V Grigor'eva, Antonina I Zhelezova, John L Vandeberg, Suren M Zakian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9317183ee0b474e83fefd37577ab49c
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spelling	oai:doaj.org-article:c9317183ee0b474e83fefd37577ab49c2021-11-18T08:33:50ZDynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.1932-620310.1371/journal.pone.0088256https://doaj.org/article/c9317183ee0b474e83fefd37577ab49c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505450/?tool=EBIhttps://doaj.org/toc/1932-6203In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do not overlap. However, chromatin structure of the inactive X-chromosome during imprinted X-inactivation, especially at early stages, is still not well understood. In this work, we studied chromatin modifications associated with the inactive X-chromosome at different stages of imprinted X-inactivation in a rodent, Microtus levis. It has been found that imprinted X-inactivation in vole occurs in a species-specific manner in two steps. The inactive X-chromosome at early stages of imprinted X-inactivation is characterized by accumulation of H3K9me3, HP1, H4K20me3, and uH2A, resembling to some extent the pattern of repressive chromatin modifications of meiotic sex chromatin. Later, the inactive X-chromosome recruits trimethylated H3K27 and acquires the two types of heterochromatin associated with random X-inactivation.Evgeniya A VaskovaElena V DementyevaAlexander I ShevchenkoSophia V PavlovaElena V Grigor'evaAntonina I ZhelezovaJohn L VandebergSuren M ZakianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88256 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evgeniya A Vaskova Elena V Dementyeva Alexander I Shevchenko Sophia V Pavlova Elena V Grigor'eva Antonina I Zhelezova John L Vandeberg Suren M Zakian Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.
description	In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate and do not overlap. However, chromatin structure of the inactive X-chromosome during imprinted X-inactivation, especially at early stages, is still not well understood. In this work, we studied chromatin modifications associated with the inactive X-chromosome at different stages of imprinted X-inactivation in a rodent, Microtus levis. It has been found that imprinted X-inactivation in vole occurs in a species-specific manner in two steps. The inactive X-chromosome at early stages of imprinted X-inactivation is characterized by accumulation of H3K9me3, HP1, H4K20me3, and uH2A, resembling to some extent the pattern of repressive chromatin modifications of meiotic sex chromatin. Later, the inactive X-chromosome recruits trimethylated H3K27 and acquires the two types of heterochromatin associated with random X-inactivation.
format	article
author	Evgeniya A Vaskova Elena V Dementyeva Alexander I Shevchenko Sophia V Pavlova Elena V Grigor'eva Antonina I Zhelezova John L Vandeberg Suren M Zakian
author_facet	Evgeniya A Vaskova Elena V Dementyeva Alexander I Shevchenko Sophia V Pavlova Elena V Grigor'eva Antonina I Zhelezova John L Vandeberg Suren M Zakian
author_sort	Evgeniya A Vaskova
title	Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.
title_short	Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.
title_full	Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.
title_fullStr	Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.
title_full_unstemmed	Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.
title_sort	dynamics of the two heterochromatin types during imprinted x chromosome inactivation in vole microtus levis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c9317183ee0b474e83fefd37577ab49c
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_version_	1718421647124332544

Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.

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