Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

Targeting virulence rather than bacterial growth is less likely to select for antibiotic resistance, but many possible targets function in both processes. Here, the authors reconstruct a genome-scale metabolic network ofP. aeruginosastrain PA14 and update that of strain PAO1, which, together with mu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer A. Bartell, Anna S. Blazier, Phillip Yen, Juliane C. Thøgersen, Lars Jelsbak, Joanna B. Goldberg, Jason A. Papin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c931cf703ea8471590b83e82e335a918
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c931cf703ea8471590b83e82e335a918
record_format	dspace
spelling	oai:doaj.org-article:c931cf703ea8471590b83e82e335a9182021-12-02T17:06:16ZReconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis10.1038/ncomms146312041-1723https://doaj.org/article/c931cf703ea8471590b83e82e335a9182017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14631https://doaj.org/toc/2041-1723Targeting virulence rather than bacterial growth is less likely to select for antibiotic resistance, but many possible targets function in both processes. Here, the authors reconstruct a genome-scale metabolic network ofP. aeruginosastrain PA14 and update that of strain PAO1, which, together with mutant screens, enable them to identify genes uniquely critical for virulence factor production.Jennifer A. BartellAnna S. BlazierPhillip YenJuliane C. ThøgersenLars JelsbakJoanna B. GoldbergJason A. PapinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer A. Bartell Anna S. Blazier Phillip Yen Juliane C. Thøgersen Lars Jelsbak Joanna B. Goldberg Jason A. Papin Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
description	Targeting virulence rather than bacterial growth is less likely to select for antibiotic resistance, but many possible targets function in both processes. Here, the authors reconstruct a genome-scale metabolic network ofP. aeruginosastrain PA14 and update that of strain PAO1, which, together with mutant screens, enable them to identify genes uniquely critical for virulence factor production.
format	article
author	Jennifer A. Bartell Anna S. Blazier Phillip Yen Juliane C. Thøgersen Lars Jelsbak Joanna B. Goldberg Jason A. Papin
author_facet	Jennifer A. Bartell Anna S. Blazier Phillip Yen Juliane C. Thøgersen Lars Jelsbak Joanna B. Goldberg Jason A. Papin
author_sort	Jennifer A. Bartell
title	Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
title_short	Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
title_full	Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
title_fullStr	Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
title_full_unstemmed	Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
title_sort	reconstruction of the metabolic network of pseudomonas aeruginosa to interrogate virulence factor synthesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c931cf703ea8471590b83e82e335a918
work_keys_str_mv	AT jenniferabartell reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis AT annasblazier reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis AT phillipyen reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis AT julianecthøgersen reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis AT larsjelsbak reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis AT joannabgoldberg reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis AT jasonapapin reconstructionofthemetabolicnetworkofpseudomonasaeruginosatointerrogatevirulencefactorsynthesis
_version_	1718381699394437120

Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

Ejemplares similares