Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices

An auxetic structure utilizing a negative Poisson’s ratio, which can expand transversally when axially expanded under tensional force, has not yet been studied in the tissue engineering and biomedical area. However, the recent advent of new technologies, such as additive manufacturing or 3D printing...

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Autores principales:	Yujin Kim, Kuk Hui Son, Jin Woo Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	auxetic scaffold tissue engineering biomedical device Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/c9335ae82e384a058d636e95a2e920dc
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spelling	oai:doaj.org-article:c9335ae82e384a058d636e95a2e920dc2021-11-25T18:13:52ZAuxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices10.3390/ma142268211996-1944https://doaj.org/article/c9335ae82e384a058d636e95a2e920dc2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6821https://doaj.org/toc/1996-1944An auxetic structure utilizing a negative Poisson’s ratio, which can expand transversally when axially expanded under tensional force, has not yet been studied in the tissue engineering and biomedical area. However, the recent advent of new technologies, such as additive manufacturing or 3D printing, has showed prospective results aimed at producing three-dimensional structures. Auxetic structures are fabricated by additive manufacturing, soft lithography, machining technology, compressed foaming, and textile fabrication using various biomaterials, including poly(ethylene glycol diacrylate), polyurethane, poly(lactic-glycolic acid), chitosan, hydroxyapatite, and using a hard material such as a silicon wafer. After fabricating the scaffold with an auxetic effect, researchers have cultured fibroblasts, osteoblasts, chondrocytes, myoblasts, and various stem cells, including mesenchymal stem cells, bone marrow stem cells, and embryonic stem cells. Additionally, they have shown new possibilities as scaffolds through tissue engineering by cell proliferation, migration, alignment, differentiation, and target tissue regeneration. In addition, auxetic structures and their unique deformation characteristics have been explored in several biomedical devices, including implants, stents, and surgical screws. Although still in the early stages, the auxetic structure, which can create mechanical properties tailored to natural tissue by changing the internal architecture of the structure, is expected to show an improved tissue reconstruction ability. In addition, continuous research at the cellular level using the auxetic micro and nano-environment could provide a breakthrough for tissue reconstruction.Yujin KimKuk Hui SonJin Woo LeeMDPI AGarticleauxeticscaffoldtissue engineeringbiomedicaldeviceTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6821, p 6821 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	auxetic scaffold tissue engineering biomedical device Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	auxetic scaffold tissue engineering biomedical device Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Yujin Kim Kuk Hui Son Jin Woo Lee Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices
description	An auxetic structure utilizing a negative Poisson’s ratio, which can expand transversally when axially expanded under tensional force, has not yet been studied in the tissue engineering and biomedical area. However, the recent advent of new technologies, such as additive manufacturing or 3D printing, has showed prospective results aimed at producing three-dimensional structures. Auxetic structures are fabricated by additive manufacturing, soft lithography, machining technology, compressed foaming, and textile fabrication using various biomaterials, including poly(ethylene glycol diacrylate), polyurethane, poly(lactic-glycolic acid), chitosan, hydroxyapatite, and using a hard material such as a silicon wafer. After fabricating the scaffold with an auxetic effect, researchers have cultured fibroblasts, osteoblasts, chondrocytes, myoblasts, and various stem cells, including mesenchymal stem cells, bone marrow stem cells, and embryonic stem cells. Additionally, they have shown new possibilities as scaffolds through tissue engineering by cell proliferation, migration, alignment, differentiation, and target tissue regeneration. In addition, auxetic structures and their unique deformation characteristics have been explored in several biomedical devices, including implants, stents, and surgical screws. Although still in the early stages, the auxetic structure, which can create mechanical properties tailored to natural tissue by changing the internal architecture of the structure, is expected to show an improved tissue reconstruction ability. In addition, continuous research at the cellular level using the auxetic micro and nano-environment could provide a breakthrough for tissue reconstruction.
format	article
author	Yujin Kim Kuk Hui Son Jin Woo Lee
author_facet	Yujin Kim Kuk Hui Son Jin Woo Lee
author_sort	Yujin Kim
title	Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices
title_short	Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices
title_full	Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices
title_fullStr	Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices
title_full_unstemmed	Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices
title_sort	auxetic structures for tissue engineering scaffolds and biomedical devices
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c9335ae82e384a058d636e95a2e920dc
work_keys_str_mv	AT yujinkim auxeticstructuresfortissueengineeringscaffoldsandbiomedicaldevices AT kukhuison auxeticstructuresfortissueengineeringscaffoldsandbiomedicaldevices AT jinwoolee auxeticstructuresfortissueengineeringscaffoldsandbiomedicaldevices
_version_	1718411465488072704

Auxetic Structures for Tissue Engineering Scaffolds and Biomedical Devices

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