Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells.

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Autores principales:	Elliot H. Akama-Garren, Theo van den Broek, Lea Simoni, Carlos Castrillon, Cees E. van der Poel, Michael C. Carroll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9345cccdb824c95b00d246c802d8ab3
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spelling	oai:doaj.org-article:c9345cccdb824c95b00d246c802d8ab32021-11-21T12:33:52ZFollicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease10.1038/s41467-021-27035-82041-1723https://doaj.org/article/c9345cccdb824c95b00d246c802d8ab32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27035-8https://doaj.org/toc/2041-1723Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells.Elliot H. Akama-GarrenTheo van den BroekLea SimoniCarlos CastrillonCees E. van der PoelMichael C. CarrollNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elliot H. Akama-Garren Theo van den Broek Lea Simoni Carlos Castrillon Cees E. van der Poel Michael C. Carroll Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease
description	Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells.
format	article
author	Elliot H. Akama-Garren Theo van den Broek Lea Simoni Carlos Castrillon Cees E. van der Poel Michael C. Carroll
author_facet	Elliot H. Akama-Garren Theo van den Broek Lea Simoni Carlos Castrillon Cees E. van der Poel Michael C. Carroll
author_sort	Elliot H. Akama-Garren
title	Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease
title_short	Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease
title_full	Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease
title_fullStr	Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease
title_full_unstemmed	Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease
title_sort	follicular t cells are clonally and transcriptionally distinct in b cell-driven mouse autoimmune disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9345cccdb824c95b00d246c802d8ab3
work_keys_str_mv	AT elliothakamagarren folliculartcellsareclonallyandtranscriptionallydistinctinbcelldrivenmouseautoimmunedisease AT theovandenbroek folliculartcellsareclonallyandtranscriptionallydistinctinbcelldrivenmouseautoimmunedisease AT leasimoni folliculartcellsareclonallyandtranscriptionallydistinctinbcelldrivenmouseautoimmunedisease AT carloscastrillon folliculartcellsareclonallyandtranscriptionallydistinctinbcelldrivenmouseautoimmunedisease AT ceesevanderpoel folliculartcellsareclonallyandtranscriptionallydistinctinbcelldrivenmouseautoimmunedisease AT michaelccarroll folliculartcellsareclonallyandtranscriptionallydistinctinbcelldrivenmouseautoimmunedisease
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Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

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