Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells.

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Autores principales: Elliot H. Akama-Garren, Theo van den Broek, Lea Simoni, Carlos Castrillon, Cees E. van der Poel, Michael C. Carroll
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/c9345cccdb824c95b00d246c802d8ab3
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