Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development

Elidamar Nunes de Carvalho Lima,1,2 Ricardo Sobhie Diaz,2 João Francisco Justo,3 José Roberto Castilho Piqueira1 1Telecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, Brazil; 2Infectious Diseases Division, Department of Medicine, Federal...

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Autores principales:	de Carvalho Lima EN, Diaz RS, Justo JF, Castilho Piqueira JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	carbon nanotubes-cnts functionalization nanoplatform nanovaccine immunomodulation carrier effect Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c94218a71bff45ecb3c335bc5897298d
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spelling	oai:doaj.org-article:c94218a71bff45ecb3c335bc5897298d2021-12-02T19:03:47ZAdvances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development1178-2013https://doaj.org/article/c94218a71bff45ecb3c335bc5897298d2021-08-01T00:00:00Zhttps://www.dovepress.com/advances-and-perspectives-in-the-use-of-carbon-nanotubes-in-vaccine-de-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Elidamar Nunes de Carvalho Lima,1,2 Ricardo Sobhie Diaz,2 João Francisco Justo,3 José Roberto Castilho Piqueira1 1Telecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, Brazil; 2Infectious Diseases Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil; 3Electronic Systems Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, BrazilCorrespondence: Elidamar Nunes de Carvalho LimaTelecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, Avenida Prof. Luciano Gualberto – Travessa 3 – 158, São Paulo, BrazilTel +55 11 3091-5647; +55 11 96326-5550Email elidamarnunes@usp.brAbstract: Advances in nanobiotechnology have allowed the utilization of nanotechnology through nanovaccines. Nanovaccines are powerful tools for enhancing the immunogenicity of a specific antigen and exhibit advantages over other adjuvant approaches, with features such as expanded stability, prolonged release, decreased immunotoxicity, and immunogenic selectivity. We introduce recent advances in carbon nanotubes (CNTs) to induce either a carrier effect as a nanoplatform or an immunostimulatory effect. Several studies of CNT-based nanovaccines revealed that due to the ability of CNTs to carry immunogenic molecules, they can act as nonclassical vaccines, a quality not possessed by vaccines with traditional formulations. Therefore, adapting and modifying the physicochemical properties of CNTs for use in vaccines may additionally enhance their efficacy in inducing a T cell-based immune response. Accordingly, the purpose of this study is to renew and awaken interest in and knowledge of the safe use of CNTs as adjuvants and carriers in vaccines.Keywords: carbon nanotubes-CNTs, functionalization, nanoplatform, nanovaccine, immunomodulation, carrier effectde Carvalho Lima ENDiaz RSJusto JFCastilho Piqueira JRDove Medical Pressarticlecarbon nanotubes-cntsfunctionalizationnanoplatformnanovaccineimmunomodulationcarrier effectMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 5411-5435 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon nanotubes-cnts functionalization nanoplatform nanovaccine immunomodulation carrier effect Medicine (General) R5-920
spellingShingle	carbon nanotubes-cnts functionalization nanoplatform nanovaccine immunomodulation carrier effect Medicine (General) R5-920 de Carvalho Lima EN Diaz RS Justo JF Castilho Piqueira JR Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development
description	Elidamar Nunes de Carvalho Lima,1,2 Ricardo Sobhie Diaz,2 João Francisco Justo,3 José Roberto Castilho Piqueira1 1Telecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, Brazil; 2Infectious Diseases Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil; 3Electronic Systems Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, BrazilCorrespondence: Elidamar Nunes de Carvalho LimaTelecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, Avenida Prof. Luciano Gualberto – Travessa 3 – 158, São Paulo, BrazilTel +55 11 3091-5647; +55 11 96326-5550Email elidamarnunes@usp.brAbstract: Advances in nanobiotechnology have allowed the utilization of nanotechnology through nanovaccines. Nanovaccines are powerful tools for enhancing the immunogenicity of a specific antigen and exhibit advantages over other adjuvant approaches, with features such as expanded stability, prolonged release, decreased immunotoxicity, and immunogenic selectivity. We introduce recent advances in carbon nanotubes (CNTs) to induce either a carrier effect as a nanoplatform or an immunostimulatory effect. Several studies of CNT-based nanovaccines revealed that due to the ability of CNTs to carry immunogenic molecules, they can act as nonclassical vaccines, a quality not possessed by vaccines with traditional formulations. Therefore, adapting and modifying the physicochemical properties of CNTs for use in vaccines may additionally enhance their efficacy in inducing a T cell-based immune response. Accordingly, the purpose of this study is to renew and awaken interest in and knowledge of the safe use of CNTs as adjuvants and carriers in vaccines.Keywords: carbon nanotubes-CNTs, functionalization, nanoplatform, nanovaccine, immunomodulation, carrier effect
format	article
author	de Carvalho Lima EN Diaz RS Justo JF Castilho Piqueira JR
author_facet	de Carvalho Lima EN Diaz RS Justo JF Castilho Piqueira JR
author_sort	de Carvalho Lima EN
title	Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development
title_short	Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development
title_full	Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development
title_fullStr	Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development
title_full_unstemmed	Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development
title_sort	advances and perspectives in the use of carbon nanotubes in vaccine development
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c94218a71bff45ecb3c335bc5897298d
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Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development

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