Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw

Abstract Objective Primary osteosarcoma of the jaw bones is very rare, and histological features of gnathic osteosarcoma remain obscure. The purpose of this study was to describe the clinicopathological features of gnathic osteosarcoma. Materials and methods Seven cases of gnathic osteosarcoma from...

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Autores principales:	Aya Sasaki, Hidetaka Miyashita, Miho Kawaida, Kaori Kameyama
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	intramembranous ossification jaw low‐grade osteosarcoma Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/c943404157ac49eab90c88cb9c860d75
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spelling	oai:doaj.org-article:c943404157ac49eab90c88cb9c860d752021-12-02T12:59:21ZLow‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw2057-434710.1002/cre2.442https://doaj.org/article/c943404157ac49eab90c88cb9c860d752021-12-01T00:00:00Zhttps://doi.org/10.1002/cre2.442https://doaj.org/toc/2057-4347Abstract Objective Primary osteosarcoma of the jaw bones is very rare, and histological features of gnathic osteosarcoma remain obscure. The purpose of this study was to describe the clinicopathological features of gnathic osteosarcoma. Materials and methods Seven cases of gnathic osteosarcoma from Japan diagnosed during the period between 2000 and 2016 were examined retrospectively. The histology of the surgical pathology materials was reviewed by two pathologists. Clinical information was obtained from the hospital's information system. Results Of the seven cases, two patients had secondary osteosarcomas. As for the five cases of primary osteosarcoma, their ages ranged from 26 to 58 years (mean: 36.2, median: 28). Histologically, three cases were fibrotic tumors composed of spindle‐shaped cells with mild to moderate nuclear atypia and the collagenous stroma accompanied by woven bones or mature lamellar‐like bones. Two cases had cartilage formation. MDM2 and CDK4 expression was observed in two out of three cases on immunostaining. The histopathology of these three cases was regarded as the counterpart of low‐grade osteosarcomas, namely, parosteal osteosarcoma and low‐grade central osteosarcoma, arising in long bones. Conclusions The surprisingly high incidence (60%, 3/5 cases) of low‐grade osteosarcoma explains the reason why gnathic osteosarcomas present a more favorable prognosis than osteosarcomas arising in long bones. Furthermore, it provides insight into the tumorigenesis mechanism of low‐grade osteosarcomas arising in the jaw and other sites.Aya SasakiHidetaka MiyashitaMiho KawaidaKaori KameyamaWileyarticleintramembranous ossificationjawlow‐gradeosteosarcomaDentistryRK1-715ENClinical and Experimental Dental Research, Vol 7, Iss 6, Pp 1175-1182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intramembranous ossification jaw low‐grade osteosarcoma Dentistry RK1-715
spellingShingle	intramembranous ossification jaw low‐grade osteosarcoma Dentistry RK1-715 Aya Sasaki Hidetaka Miyashita Miho Kawaida Kaori Kameyama Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw
description	Abstract Objective Primary osteosarcoma of the jaw bones is very rare, and histological features of gnathic osteosarcoma remain obscure. The purpose of this study was to describe the clinicopathological features of gnathic osteosarcoma. Materials and methods Seven cases of gnathic osteosarcoma from Japan diagnosed during the period between 2000 and 2016 were examined retrospectively. The histology of the surgical pathology materials was reviewed by two pathologists. Clinical information was obtained from the hospital's information system. Results Of the seven cases, two patients had secondary osteosarcomas. As for the five cases of primary osteosarcoma, their ages ranged from 26 to 58 years (mean: 36.2, median: 28). Histologically, three cases were fibrotic tumors composed of spindle‐shaped cells with mild to moderate nuclear atypia and the collagenous stroma accompanied by woven bones or mature lamellar‐like bones. Two cases had cartilage formation. MDM2 and CDK4 expression was observed in two out of three cases on immunostaining. The histopathology of these three cases was regarded as the counterpart of low‐grade osteosarcomas, namely, parosteal osteosarcoma and low‐grade central osteosarcoma, arising in long bones. Conclusions The surprisingly high incidence (60%, 3/5 cases) of low‐grade osteosarcoma explains the reason why gnathic osteosarcomas present a more favorable prognosis than osteosarcomas arising in long bones. Furthermore, it provides insight into the tumorigenesis mechanism of low‐grade osteosarcomas arising in the jaw and other sites.
format	article
author	Aya Sasaki Hidetaka Miyashita Miho Kawaida Kaori Kameyama
author_facet	Aya Sasaki Hidetaka Miyashita Miho Kawaida Kaori Kameyama
author_sort	Aya Sasaki
title	Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw
title_short	Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw
title_full	Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw
title_fullStr	Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw
title_full_unstemmed	Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw
title_sort	low‐grade osteosarcoma is predominant in gnathic osteosarcomas: a report of seven cases of osteosarcoma of the jaw
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c943404157ac49eab90c88cb9c860d75
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Low‐grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw

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