Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry
Natasha Bertelsen et al. develop a computational model to categorize patients with autism spectrum disorder (ASD) into distinct subgroups, based on social-communicative or restricted repetitive behaviors. By integrating publicly available neuroimaging and genetic data, they report neural and molecul...
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Nature Portfolio
2021
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oai:doaj.org-article:c94c4da54e7f411495da1401f7a3c8622021-12-02T15:43:07ZImbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry10.1038/s42003-021-02015-22399-3642https://doaj.org/article/c94c4da54e7f411495da1401f7a3c8622021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02015-2https://doaj.org/toc/2399-3642Natasha Bertelsen et al. develop a computational model to categorize patients with autism spectrum disorder (ASD) into distinct subgroups, based on social-communicative or restricted repetitive behaviors. By integrating publicly available neuroimaging and genetic data, they report neural and molecular signatures in two of these subgroups, altogether highlighting subtle differences in neural circuitry and genomic networks that could underlie phenotypic differences among ASD patients.Natasha BertelsenIsotta LandiRichard A. I. BethlehemJakob SeidlitzElena Maria BusuoliVeronica MandelliEleonora SattaStavros TrakoshisBonnie AuyeungPrantik KunduEva LothGuillaume DumasSarah BaumeisterChristian F. BeckmannSven BölteThomas BourgeronTony CharmanSarah DurstonChristine EckerRosemary J. HoltMark H. JohnsonEmily J. H. JonesLuke MasonAndreas Meyer-LindenbergCarolin MoessnangMarianne OldehinkelAntonio M. PersicoJulian TillmannSteve C. R. WilliamsWill SpoorenDeclan G. M. MurphyJan K. Buitelaarthe EU-AIMS LEAP groupSimon Baron-CohenMeng-Chuan LaiMichael V. LombardoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Natasha Bertelsen Isotta Landi Richard A. I. Bethlehem Jakob Seidlitz Elena Maria Busuoli Veronica Mandelli Eleonora Satta Stavros Trakoshis Bonnie Auyeung Prantik Kundu Eva Loth Guillaume Dumas Sarah Baumeister Christian F. Beckmann Sven Bölte Thomas Bourgeron Tony Charman Sarah Durston Christine Ecker Rosemary J. Holt Mark H. Johnson Emily J. H. Jones Luke Mason Andreas Meyer-Lindenberg Carolin Moessnang Marianne Oldehinkel Antonio M. Persico Julian Tillmann Steve C. R. Williams Will Spooren Declan G. M. Murphy Jan K. Buitelaar the EU-AIMS LEAP group Simon Baron-Cohen Meng-Chuan Lai Michael V. Lombardo Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| description |
Natasha Bertelsen et al. develop a computational model to categorize patients with autism spectrum disorder (ASD) into distinct subgroups, based on social-communicative or restricted repetitive behaviors. By integrating publicly available neuroimaging and genetic data, they report neural and molecular signatures in two of these subgroups, altogether highlighting subtle differences in neural circuitry and genomic networks that could underlie phenotypic differences among ASD patients. |
| format |
article |
| author |
Natasha Bertelsen Isotta Landi Richard A. I. Bethlehem Jakob Seidlitz Elena Maria Busuoli Veronica Mandelli Eleonora Satta Stavros Trakoshis Bonnie Auyeung Prantik Kundu Eva Loth Guillaume Dumas Sarah Baumeister Christian F. Beckmann Sven Bölte Thomas Bourgeron Tony Charman Sarah Durston Christine Ecker Rosemary J. Holt Mark H. Johnson Emily J. H. Jones Luke Mason Andreas Meyer-Lindenberg Carolin Moessnang Marianne Oldehinkel Antonio M. Persico Julian Tillmann Steve C. R. Williams Will Spooren Declan G. M. Murphy Jan K. Buitelaar the EU-AIMS LEAP group Simon Baron-Cohen Meng-Chuan Lai Michael V. Lombardo |
| author_facet |
Natasha Bertelsen Isotta Landi Richard A. I. Bethlehem Jakob Seidlitz Elena Maria Busuoli Veronica Mandelli Eleonora Satta Stavros Trakoshis Bonnie Auyeung Prantik Kundu Eva Loth Guillaume Dumas Sarah Baumeister Christian F. Beckmann Sven Bölte Thomas Bourgeron Tony Charman Sarah Durston Christine Ecker Rosemary J. Holt Mark H. Johnson Emily J. H. Jones Luke Mason Andreas Meyer-Lindenberg Carolin Moessnang Marianne Oldehinkel Antonio M. Persico Julian Tillmann Steve C. R. Williams Will Spooren Declan G. M. Murphy Jan K. Buitelaar the EU-AIMS LEAP group Simon Baron-Cohen Meng-Chuan Lai Michael V. Lombardo |
| author_sort |
Natasha Bertelsen |
| title |
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| title_short |
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| title_full |
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| title_fullStr |
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| title_full_unstemmed |
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| title_sort |
imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c94c4da54e7f411495da1401f7a3c862 |
| work_keys_str_mv |
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