CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN

Molecular mass of SCPB1 was estimated to be equal to 43.0±0.5 kDa. Immunization experiments were performed in laboratory animals to investigate the SCPB1 immunogenic properties. Maximum titers of IgG antibodies against SCPB1 (1:5,1 х 104 и 1:1,6× x 106 for mice and rabbits, respectively) indicated t...

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Autores principales:	N. V. Duplik, I. V. Koroleva, A. N. Suvorov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	streptococcus group b с5а peptidase recombinant polipeptide scpb1 immunogenesity antibodies Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c94cb76700f942cd98cf325633e81c45
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spelling	oai:doaj.org-article:c94cb76700f942cd98cf325633e81c452021-11-18T08:03:37ZCLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN1563-06252313-741X10.15789/1563-0625-2009-1-7-14https://doaj.org/article/c94cb76700f942cd98cf325633e81c452014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/34https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMolecular mass of SCPB1 was estimated to be equal to 43.0±0.5 kDa. Immunization experiments were performed in laboratory animals to investigate the SCPB1 immunogenic properties. Maximum titers of IgG antibodies against SCPB1 (1:5,1 х 104 и 1:1,6× x 106 for mice and rabbits, respectively) indicated to SCPB1 immunogenicity. Moreover, the antibodies against SCPB1 were revealed in sera from women infected with GBS thus designating the humoral immune response of human organism to C5a peptidase fragment under study. Protective properties of anti-SCPB1 antibodies against were demonstrated by experiments in vitro (opsonophagocytosis), and in vivo (a model of GBS infection in mice).N. V. DuplikI. V. KorolevaA. N. SuvorovSPb RAACIarticlestreptococcus group bс5а peptidaserecombinant polipeptide scpb1immunogenesityantibodiesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 7-14 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	streptococcus group b с5а peptidase recombinant polipeptide scpb1 immunogenesity antibodies Immunologic diseases. Allergy RC581-607
spellingShingle	streptococcus group b с5а peptidase recombinant polipeptide scpb1 immunogenesity antibodies Immunologic diseases. Allergy RC581-607 N. V. Duplik I. V. Koroleva A. N. Suvorov CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN
description	Molecular mass of SCPB1 was estimated to be equal to 43.0±0.5 kDa. Immunization experiments were performed in laboratory animals to investigate the SCPB1 immunogenic properties. Maximum titers of IgG antibodies against SCPB1 (1:5,1 х 104 и 1:1,6× x 106 for mice and rabbits, respectively) indicated to SCPB1 immunogenicity. Moreover, the antibodies against SCPB1 were revealed in sera from women infected with GBS thus designating the humoral immune response of human organism to C5a peptidase fragment under study. Protective properties of anti-SCPB1 antibodies against were demonstrated by experiments in vitro (opsonophagocytosis), and in vivo (a model of GBS infection in mice).
format	article
author	N. V. Duplik I. V. Koroleva A. N. Suvorov
author_facet	N. V. Duplik I. V. Koroleva A. N. Suvorov
author_sort	N. V. Duplik
title	CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN
title_short	CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN
title_full	CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN
title_fullStr	CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN
title_full_unstemmed	CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN
title_sort	cloning, expression and stljdy of immijnological properties of the streptococci group b c5a peptidase recombinant protein
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c94cb76700f942cd98cf325633e81c45
work_keys_str_mv	AT nvduplik cloningexpressionandstljdyofimmijnologicalpropertiesofthestreptococcigroupbc5apeptidaserecombinantprotein AT ivkoroleva cloningexpressionandstljdyofimmijnologicalpropertiesofthestreptococcigroupbc5apeptidaserecombinantprotein AT ansuvorov cloningexpressionandstljdyofimmijnologicalpropertiesofthestreptococcigroupbc5apeptidaserecombinantprotein
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CLONING, EXPRESSION AND STLJDY OF IMMIJNOLOGICAL PROPERTIES OF THE STREPTOCOCCI GROUP B C5A PEPTIDASE RECOMBINANT PROTEIN

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