Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We dem...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Melissa Payet, Farouk Dargai, Philippe Gasque, Xavier Guillot
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	rheumatoid arthritis epigenetic regulation miR-155 miR-146a miR-150 miR-410-3p DNA methylation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c94f5a5a6d824434aab1b86f9c8a41bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c94f5a5a6d824434aab1b86f9c8a41bb
record_format	dspace
spelling	oai:doaj.org-article:c94f5a5a6d824434aab1b86f9c8a41bb2021-11-25T17:54:02ZEpigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review10.3390/ijms2222121701422-00671661-6596https://doaj.org/article/c94f5a5a6d824434aab1b86f9c8a41bb2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12170https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.Melissa PayetFarouk DargaiPhilippe GasqueXavier GuillotMDPI AGarticlerheumatoid arthritis epigenetic regulationmiR-155miR-146amiR-150miR-410-3pDNA methylationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12170, p 12170 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis epigenetic regulation miR-155 miR-146a miR-150 miR-410-3p DNA methylation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	rheumatoid arthritis epigenetic regulation miR-155 miR-146a miR-150 miR-410-3p DNA methylation Biology (General) QH301-705.5 Chemistry QD1-999 Melissa Payet Farouk Dargai Philippe Gasque Xavier Guillot Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
description	The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.
format	article
author	Melissa Payet Farouk Dargai Philippe Gasque Xavier Guillot
author_facet	Melissa Payet Farouk Dargai Philippe Gasque Xavier Guillot
author_sort	Melissa Payet
title	Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
title_short	Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
title_full	Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
title_fullStr	Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
title_full_unstemmed	Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review
title_sort	epigenetic regulation (including micro-rnas, dna methylation and histone modifications) of rheumatoid arthritis: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c94f5a5a6d824434aab1b86f9c8a41bb
work_keys_str_mv	AT melissapayet epigeneticregulationincludingmicrornasdnamethylationandhistonemodificationsofrheumatoidarthritisasystematicreview AT faroukdargai epigeneticregulationincludingmicrornasdnamethylationandhistonemodificationsofrheumatoidarthritisasystematicreview AT philippegasque epigeneticregulationincludingmicrornasdnamethylationandhistonemodificationsofrheumatoidarthritisasystematicreview AT xavierguillot epigeneticregulationincludingmicrornasdnamethylationandhistonemodificationsofrheumatoidarthritisasystematicreview
_version_	1718411887408840704

Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

Ejemplares similares