Evaluation of Wound Healing Potential of Novel Hydrogel Based on Ocimum basilicum and Trifolium pratense Extracts

Plants are an inexhaustible source of compounds with different medicinal properties, suitable as alternative options for the prevention and treatment of various pathologies. They are safe, effective and economical. In this paper, a combined extract made of Ocimum basilicum and <...

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Autores principales:	Ina Andreea Antonescu (Mintaș), Angela Antonescu, Florina Miere (Groza), Luminița Fritea, Alin Cristian Teușdea, Laura Vicaș, Simona Ioana Vicaș, Ilarie Brihan, Maria Domuța, Mihaela Zdrinca, Marcel Zdrinca, Simona Cavalu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Ocimum basilicum</i> <i>Trifolium pratense</i> hydrogel scratch assay in vitro and in vivo tests <i>Psoriasis vulgaris</i> Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c950752fc9ca43b79901566f15102adf
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spelling	oai:doaj.org-article:c950752fc9ca43b79901566f15102adf2021-11-25T18:52:19ZEvaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts10.3390/pr91120962227-9717https://doaj.org/article/c950752fc9ca43b79901566f15102adf2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9717/9/11/2096https://doaj.org/toc/2227-9717Plants are an inexhaustible source of compounds with different medicinal properties, suitable as alternative options for the prevention and treatment of various pathologies. They are safe, effective and economical. In this paper, a combined extract made of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> extracts (EOT) was used for the first time to demonstrate its healing effect on dermal pathologies. To evaluate the wound healing effect of EOT, a novel gel formulation was prepared and subsequently tested in vitro (using the scratch test assay) and in vivo (on an animal model). The in vitro tests demonstrated the complete recovery of the dermal fibroblast monolayer when treated with EOT in a concentration of 50 µg/mL. In vivo results using a hydrogel formulation based on EOT demonstrated improved wound contraction time and complete healing after 13 days of treatment. Moreover, a clinical case of <i>Psoriasis vulgaris</i> was presented, in which one week of treatment led to the significant improvement of the patient’s health. In conclusion, the topical use of the novel gel formulation containing EOT is a successful therapeutic alternative in the treatment of dermal diseases.Ina Andreea Antonescu (Mintaș)Angela AntonescuFlorina Miere (Groza)Luminița FriteaAlin Cristian TeușdeaLaura VicașSimona Ioana VicașIlarie BrihanMaria DomuțaMihaela ZdrincaMarcel ZdrincaSimona CavaluMDPI AGarticle<i>Ocimum basilicum</i><i>Trifolium pratense</i>hydrogelscratch assayin vitro and in vivo tests<i>Psoriasis vulgaris</i>Chemical technologyTP1-1185ChemistryQD1-999ENProcesses, Vol 9, Iss 2096, p 2096 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Ocimum basilicum</i> <i>Trifolium pratense</i> hydrogel scratch assay in vitro and in vivo tests <i>Psoriasis vulgaris</i> Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	<i>Ocimum basilicum</i> <i>Trifolium pratense</i> hydrogel scratch assay in vitro and in vivo tests <i>Psoriasis vulgaris</i> Chemical technology TP1-1185 Chemistry QD1-999 Ina Andreea Antonescu (Mintaș) Angela Antonescu Florina Miere (Groza) Luminița Fritea Alin Cristian Teușdea Laura Vicaș Simona Ioana Vicaș Ilarie Brihan Maria Domuța Mihaela Zdrinca Marcel Zdrinca Simona Cavalu Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts
description	Plants are an inexhaustible source of compounds with different medicinal properties, suitable as alternative options for the prevention and treatment of various pathologies. They are safe, effective and economical. In this paper, a combined extract made of <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> extracts (EOT) was used for the first time to demonstrate its healing effect on dermal pathologies. To evaluate the wound healing effect of EOT, a novel gel formulation was prepared and subsequently tested in vitro (using the scratch test assay) and in vivo (on an animal model). The in vitro tests demonstrated the complete recovery of the dermal fibroblast monolayer when treated with EOT in a concentration of 50 µg/mL. In vivo results using a hydrogel formulation based on EOT demonstrated improved wound contraction time and complete healing after 13 days of treatment. Moreover, a clinical case of <i>Psoriasis vulgaris</i> was presented, in which one week of treatment led to the significant improvement of the patient’s health. In conclusion, the topical use of the novel gel formulation containing EOT is a successful therapeutic alternative in the treatment of dermal diseases.
format	article
author	Ina Andreea Antonescu (Mintaș) Angela Antonescu Florina Miere (Groza) Luminița Fritea Alin Cristian Teușdea Laura Vicaș Simona Ioana Vicaș Ilarie Brihan Maria Domuța Mihaela Zdrinca Marcel Zdrinca Simona Cavalu
author_facet	Ina Andreea Antonescu (Mintaș) Angela Antonescu Florina Miere (Groza) Luminița Fritea Alin Cristian Teușdea Laura Vicaș Simona Ioana Vicaș Ilarie Brihan Maria Domuța Mihaela Zdrinca Marcel Zdrinca Simona Cavalu
author_sort	Ina Andreea Antonescu (Mintaș)
title	Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts
title_short	Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts
title_full	Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts
title_fullStr	Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts
title_full_unstemmed	Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts
title_sort	evaluation of wound healing potential of novel hydrogel based on <i>ocimum basilicum</i> and <i>trifolium pratense</i> extracts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c950752fc9ca43b79901566f15102adf
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Evaluation of Wound Healing Potential of Novel Hydrogel Based on <i>Ocimum basilicum</i> and <i>Trifolium pratense</i> Extracts

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