Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung

Abstract The prognostic role of histological patterns of dominant tumor (DT) and second dominant tumor (sDT) in synchronous multiple adenocarcinoma (SMADC) of lung remains unclear. SMADC patients diagnosed between 2003 and 2015 were retrospectively reviewed. DT and sDT were defined as two maximum di...

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Autores principales:	Ping-Chung Tsai, Chia Liu, Yi-Chen Yeh, Chun-Ku Chen, Po-Kuei Hsu, Hui-Shan Chen, Chien-Sheng Huang, Chih-Cheng Hsieh, Han-Shui Hsu, Biing-Shiun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c952c3d9a73a4ef4b0d96d6d877e4680
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spelling	oai:doaj.org-article:c952c3d9a73a4ef4b0d96d6d877e46802021-12-02T14:29:03ZPrognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung10.1038/s41598-021-88193-92045-2322https://doaj.org/article/c952c3d9a73a4ef4b0d96d6d877e46802021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88193-9https://doaj.org/toc/2045-2322Abstract The prognostic role of histological patterns of dominant tumor (DT) and second dominant tumor (sDT) in synchronous multiple adenocarcinoma (SMADC) of lung remains unclear. SMADC patients diagnosed between 2003 and 2015 were retrospectively reviewed. DT and sDT were defined as two maximum diameters of consolidation among multiple tumors. Histological pattern was determined using IASLC/ATS/ERS classification system. DTs were divided into low- (lepidic), intermediate- (acinar, papillary) and high-grade (micropapillary, solid) subtypes, and sDTs into non-invasive predominant (lepidic) and invasive predominant (acinar, papillary, micropapillary, solid) subtypes. During mean 74-month follow-up among 149 nodal-negative patients having SMADC resected, recurrence was noted in 44 (29.5%), with significantly higher percentage in high-grade DT (p < 0.001). Five-year overall (OS) and disease-free (DFS) survivals in low-, intermediate- and high-grade DT were 96.9%, 94.3%, 63.3% (p < 0.001) and 100%, 87.2%, 30.0%, respectively (p < 0.001). Cox-regression multivariate analysis demonstrated high-grade DT as a significant predictor for DFS (Hazard ratio [HR] 5.324; 95% CI 2.570–11.462, p < 0.001) and OS (HR 3.287; 95% CI 1.323–8.168, p = 0.010). Analyzing DT and sDT together, we found no significant differences in DFS, either in intermediate- or high-grade DT plus invasive or non-invasive sDT. DT was histologically an independent risk factor of DFS and OS in completely resected nodal-negative SMADCs.Ping-Chung TsaiChia LiuYi-Chen YehChun-Ku ChenPo-Kuei HsuHui-Shan ChenChien-Sheng HuangChih-Cheng HsiehHan-Shui HsuBiing-Shiun HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping-Chung Tsai Chia Liu Yi-Chen Yeh Chun-Ku Chen Po-Kuei Hsu Hui-Shan Chen Chien-Sheng Huang Chih-Cheng Hsieh Han-Shui Hsu Biing-Shiun Huang Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
description	Abstract The prognostic role of histological patterns of dominant tumor (DT) and second dominant tumor (sDT) in synchronous multiple adenocarcinoma (SMADC) of lung remains unclear. SMADC patients diagnosed between 2003 and 2015 were retrospectively reviewed. DT and sDT were defined as two maximum diameters of consolidation among multiple tumors. Histological pattern was determined using IASLC/ATS/ERS classification system. DTs were divided into low- (lepidic), intermediate- (acinar, papillary) and high-grade (micropapillary, solid) subtypes, and sDTs into non-invasive predominant (lepidic) and invasive predominant (acinar, papillary, micropapillary, solid) subtypes. During mean 74-month follow-up among 149 nodal-negative patients having SMADC resected, recurrence was noted in 44 (29.5%), with significantly higher percentage in high-grade DT (p < 0.001). Five-year overall (OS) and disease-free (DFS) survivals in low-, intermediate- and high-grade DT were 96.9%, 94.3%, 63.3% (p < 0.001) and 100%, 87.2%, 30.0%, respectively (p < 0.001). Cox-regression multivariate analysis demonstrated high-grade DT as a significant predictor for DFS (Hazard ratio [HR] 5.324; 95% CI 2.570–11.462, p < 0.001) and OS (HR 3.287; 95% CI 1.323–8.168, p = 0.010). Analyzing DT and sDT together, we found no significant differences in DFS, either in intermediate- or high-grade DT plus invasive or non-invasive sDT. DT was histologically an independent risk factor of DFS and OS in completely resected nodal-negative SMADCs.
format	article
author	Ping-Chung Tsai Chia Liu Yi-Chen Yeh Chun-Ku Chen Po-Kuei Hsu Hui-Shan Chen Chien-Sheng Huang Chih-Cheng Hsieh Han-Shui Hsu Biing-Shiun Huang
author_facet	Ping-Chung Tsai Chia Liu Yi-Chen Yeh Chun-Ku Chen Po-Kuei Hsu Hui-Shan Chen Chien-Sheng Huang Chih-Cheng Hsieh Han-Shui Hsu Biing-Shiun Huang
author_sort	Ping-Chung Tsai
title	Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
title_short	Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
title_full	Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
title_fullStr	Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
title_full_unstemmed	Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
title_sort	prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c952c3d9a73a4ef4b0d96d6d877e4680
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Prognostic histologic subtyping of dominant tumor in resected synchronous multiple adenocarcinomas of lung

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