Stress-induced differential gene expression in cardiac tissue

Abstract The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as part of the stress response over activate beta adrenoceptors (β-AR) in the heart. Whether and how stress affects the expression of co...

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Autores principales:	Ana Elisa T. S. de Carvalho, Marco A. Cordeiro, Luana S. Rodrigues, Daniela Ortolani, Regina C. Spadari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c954db47b43a4754ae716783911354d4
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spelling	oai:doaj.org-article:c954db47b43a4754ae716783911354d42021-12-02T17:39:20ZStress-induced differential gene expression in cardiac tissue10.1038/s41598-021-88267-82045-2322https://doaj.org/article/c954db47b43a4754ae716783911354d42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88267-8https://doaj.org/toc/2045-2322Abstract The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as part of the stress response over activate beta adrenoceptors (β-AR) in the heart. Whether and how stress affects the expression of components of the intracellular environment in the heart is still, however, unknown. This paper used microarray to analyze the gene expression in the left ventricle wall of rats submitted to foot shock stress, treated or not treated with the selective β2-AR antagonist ICI118,551 (ICI), compared to those of non-stressed rats also treated or not with ICI, respectively. The main findings were that stress induces changes in gene expression in the heart and that β2-AR plays a role in this process. The vast majority of genes disregulated by stress were exclusive for only one of the comparisons, indicating that, in the same stressful situation, the profile of gene expression in the heart is substantially different when the β2-AR is active or when it is blocked. Stress induced alterations in the expression of such a large number of genes seems to be part of stress-induced adaptive mechanism.Ana Elisa T. S. de CarvalhoMarco A. CordeiroLuana S. RodriguesDaniela OrtolaniRegina C. SpadariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Elisa T. S. de Carvalho Marco A. Cordeiro Luana S. Rodrigues Daniela Ortolani Regina C. Spadari Stress-induced differential gene expression in cardiac tissue
description	Abstract The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as part of the stress response over activate beta adrenoceptors (β-AR) in the heart. Whether and how stress affects the expression of components of the intracellular environment in the heart is still, however, unknown. This paper used microarray to analyze the gene expression in the left ventricle wall of rats submitted to foot shock stress, treated or not treated with the selective β2-AR antagonist ICI118,551 (ICI), compared to those of non-stressed rats also treated or not with ICI, respectively. The main findings were that stress induces changes in gene expression in the heart and that β2-AR plays a role in this process. The vast majority of genes disregulated by stress were exclusive for only one of the comparisons, indicating that, in the same stressful situation, the profile of gene expression in the heart is substantially different when the β2-AR is active or when it is blocked. Stress induced alterations in the expression of such a large number of genes seems to be part of stress-induced adaptive mechanism.
format	article
author	Ana Elisa T. S. de Carvalho Marco A. Cordeiro Luana S. Rodrigues Daniela Ortolani Regina C. Spadari
author_facet	Ana Elisa T. S. de Carvalho Marco A. Cordeiro Luana S. Rodrigues Daniela Ortolani Regina C. Spadari
author_sort	Ana Elisa T. S. de Carvalho
title	Stress-induced differential gene expression in cardiac tissue
title_short	Stress-induced differential gene expression in cardiac tissue
title_full	Stress-induced differential gene expression in cardiac tissue
title_fullStr	Stress-induced differential gene expression in cardiac tissue
title_full_unstemmed	Stress-induced differential gene expression in cardiac tissue
title_sort	stress-induced differential gene expression in cardiac tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c954db47b43a4754ae716783911354d4
work_keys_str_mv	AT anaelisatsdecarvalho stressinduceddifferentialgeneexpressionincardiactissue AT marcoacordeiro stressinduceddifferentialgeneexpressionincardiactissue AT luanasrodrigues stressinduceddifferentialgeneexpressionincardiactissue AT danielaortolani stressinduceddifferentialgeneexpressionincardiactissue AT reginacspadari stressinduceddifferentialgeneexpressionincardiactissue
_version_	1718379847880802304

Stress-induced differential gene expression in cardiac tissue

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