Clonal astrocytic response to cortical injury.

Astrocytes are a heterogeneous population of glial cells with multifaceted roles in the central nervous system. Recently, the new method for the clonal analysis Star Track evidenced the link between astrocyte heterogeneity and lineage. Here, we tested the morphological response to mechanical injury...

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Autores principales:	Eduardo Martín-López, Jorge García-Marques, Raúl Núñez-Llaves, Laura López-Mascaraque
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c958f27ccfce457ca6c9625f607c855a
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spelling	oai:doaj.org-article:c958f27ccfce457ca6c9625f607c855a2021-11-18T08:56:00ZClonal astrocytic response to cortical injury.1932-620310.1371/journal.pone.0074039https://doaj.org/article/c958f27ccfce457ca6c9625f607c855a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040158/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Astrocytes are a heterogeneous population of glial cells with multifaceted roles in the central nervous system. Recently, the new method for the clonal analysis Star Track evidenced the link between astrocyte heterogeneity and lineage. Here, we tested the morphological response to mechanical injury of clonally related astrocytes using the Star Track approach, which labels each cell lineage with a specific code of colors. Histological and immunohistochemical analyses at 7 days post injury revealed a variety of morphological changes that were different among distinct clones. In many cases, cells of the same clone responded equally to the injury, suggesting the dependence on their genetic codification (intrinsic response). However, in other cases cells of the same clone responded differently to the injury, indicating their response to extrinsic factors. Thus, whereas some clones exhibited a strong morphological alteration or a high proliferative response to the injury, other clones located at similar distances to the lesion were apparently unresponsive. Concurrence of different clonal responses to the injury reveals the importance of the development determining the astrocyte features in response to brain injuries. These features should be considered to develop therapies that affect glial function.Eduardo Martín-LópezJorge García-MarquesRaúl Núñez-LlavesLaura López-MascaraquePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74039 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eduardo Martín-López Jorge García-Marques Raúl Núñez-Llaves Laura López-Mascaraque Clonal astrocytic response to cortical injury.
description	Astrocytes are a heterogeneous population of glial cells with multifaceted roles in the central nervous system. Recently, the new method for the clonal analysis Star Track evidenced the link between astrocyte heterogeneity and lineage. Here, we tested the morphological response to mechanical injury of clonally related astrocytes using the Star Track approach, which labels each cell lineage with a specific code of colors. Histological and immunohistochemical analyses at 7 days post injury revealed a variety of morphological changes that were different among distinct clones. In many cases, cells of the same clone responded equally to the injury, suggesting the dependence on their genetic codification (intrinsic response). However, in other cases cells of the same clone responded differently to the injury, indicating their response to extrinsic factors. Thus, whereas some clones exhibited a strong morphological alteration or a high proliferative response to the injury, other clones located at similar distances to the lesion were apparently unresponsive. Concurrence of different clonal responses to the injury reveals the importance of the development determining the astrocyte features in response to brain injuries. These features should be considered to develop therapies that affect glial function.
format	article
author	Eduardo Martín-López Jorge García-Marques Raúl Núñez-Llaves Laura López-Mascaraque
author_facet	Eduardo Martín-López Jorge García-Marques Raúl Núñez-Llaves Laura López-Mascaraque
author_sort	Eduardo Martín-López
title	Clonal astrocytic response to cortical injury.
title_short	Clonal astrocytic response to cortical injury.
title_full	Clonal astrocytic response to cortical injury.
title_fullStr	Clonal astrocytic response to cortical injury.
title_full_unstemmed	Clonal astrocytic response to cortical injury.
title_sort	clonal astrocytic response to cortical injury.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c958f27ccfce457ca6c9625f607c855a
work_keys_str_mv	AT eduardomartinlopez clonalastrocyticresponsetocorticalinjury AT jorgegarciamarques clonalastrocyticresponsetocorticalinjury AT raulnunezllaves clonalastrocyticresponsetocorticalinjury AT lauralopezmascaraque clonalastrocyticresponsetocorticalinjury
_version_	1718421166336507904

Clonal astrocytic response to cortical injury.

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