Vomocytosis: Too Much Booze, Base, or Calcium?

ABSTRACT Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules. However, some pathogenic agents have the ability to eva...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Melissa Cruz-Acuña, Noah Pacifici, Jamal S. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	vomocytosis macrophage pH phagosome nonlytic exocytosis Cryptococcus neoformans Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c95e966711ad49719169c56f291b093e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c95e966711ad49719169c56f291b093e
record_format	dspace
spelling	oai:doaj.org-article:c95e966711ad49719169c56f291b093e2021-11-15T15:54:47ZVomocytosis: Too Much Booze, Base, or Calcium?10.1128/mBio.02526-192150-7511https://doaj.org/article/c95e966711ad49719169c56f291b093e2019-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02526-19https://doaj.org/toc/2150-7511ABSTRACT Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules. However, some pathogenic agents have the ability to evade this endosomal degradation through a nonlytic exocytosis process termed vomocytosis. This phenomenon has been most often studied for Cryptococcus neoformans, a yeast that causes roughly 180,000 deaths per year, primarily in immunocompromised (e.g., human immunodeficiency virus [HIV]) patients. Existing dogma purports that vomocytosis involves distinctive cellular pathways and intracellular physicochemical cues in the host cell during phagosomal maturation. Moreover, it has been observed that the immunological state of the individual and macrophage phenotype affect vomocytosis outcomes. Here we compile the current knowledge on the factors (with respect to the phagocytic cell) that promote vomocytosis of C. neoformans from macrophages.Melissa Cruz-AcuñaNoah PacificiJamal S. LewisAmerican Society for MicrobiologyarticlevomocytosismacrophagepHphagosomenonlytic exocytosisCryptococcus neoformansMicrobiologyQR1-502ENmBio, Vol 10, Iss 6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vomocytosis macrophage pH phagosome nonlytic exocytosis Cryptococcus neoformans Microbiology QR1-502
spellingShingle	vomocytosis macrophage pH phagosome nonlytic exocytosis Cryptococcus neoformans Microbiology QR1-502 Melissa Cruz-Acuña Noah Pacifici Jamal S. Lewis Vomocytosis: Too Much Booze, Base, or Calcium?
description	ABSTRACT Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules. However, some pathogenic agents have the ability to evade this endosomal degradation through a nonlytic exocytosis process termed vomocytosis. This phenomenon has been most often studied for Cryptococcus neoformans, a yeast that causes roughly 180,000 deaths per year, primarily in immunocompromised (e.g., human immunodeficiency virus [HIV]) patients. Existing dogma purports that vomocytosis involves distinctive cellular pathways and intracellular physicochemical cues in the host cell during phagosomal maturation. Moreover, it has been observed that the immunological state of the individual and macrophage phenotype affect vomocytosis outcomes. Here we compile the current knowledge on the factors (with respect to the phagocytic cell) that promote vomocytosis of C. neoformans from macrophages.
format	article
author	Melissa Cruz-Acuña Noah Pacifici Jamal S. Lewis
author_facet	Melissa Cruz-Acuña Noah Pacifici Jamal S. Lewis
author_sort	Melissa Cruz-Acuña
title	Vomocytosis: Too Much Booze, Base, or Calcium?
title_short	Vomocytosis: Too Much Booze, Base, or Calcium?
title_full	Vomocytosis: Too Much Booze, Base, or Calcium?
title_fullStr	Vomocytosis: Too Much Booze, Base, or Calcium?
title_full_unstemmed	Vomocytosis: Too Much Booze, Base, or Calcium?
title_sort	vomocytosis: too much booze, base, or calcium?
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/c95e966711ad49719169c56f291b093e
work_keys_str_mv	AT melissacruzacuna vomocytosistoomuchboozebaseorcalcium AT noahpacifici vomocytosistoomuchboozebaseorcalcium AT jamalslewis vomocytosistoomuchboozebaseorcalcium
_version_	1718427243431067648

Vomocytosis: Too Much Booze, Base, or Calcium?

Ejemplares similares