Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia

Introduction The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia. Material and methods Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated di...

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Autores principales:	Chunli Han, Zhanchao Xian, Yang Zou, Zhiyong Liao, Rongfeng Yang, Chunxia Zou, Xiaoqing Wang, Yan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	hypertension flow-mediated dilation hyperuricemia Medicine R
Acceso en línea:	https://doaj.org/article/c95fa6fb0ac2467e8b483cda965940bc
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spelling	oai:doaj.org-article:c95fa6fb0ac2467e8b483cda965940bc2021-12-02T16:58:44ZFlow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia1734-19221896-915110.5114/aoms.2018.73856https://doaj.org/article/c95fa6fb0ac2467e8b483cda965940bc2019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Flow-mediated-dilation-can-be-used-to-predict-incident-hypertension-in-patients-with,81637,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia. Material and methods Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated dilation was assessed at baseline, and after 1 year’s follow-up the incidence of hypertension was compared between those with and without hyperuricemia. The predictive value of baseline FMD for incident hypertension among hyperuricemia patients was evaluated. Results A total of 222 participants were included. Mean systolic and diastolic blood pressure (BP) was 129.5 ±8.4 mm Hg and 78.3 ±7.9 mm Hg. Mean serum uric acid (UA) level was 4.4 ±2.8 mg/dl. Mean FMD was 5.1 ±2.7%. Compared to normal UA group, hyperuricemia group had higher proportion of male (58.4% vs. 61.2%), higher systolic BP (125.4 ±7.9 mm Hg vs. 132.1 ±7.3 mm Hg), serum high sensitivity C-reactive protein (3.9 ±2.2 mg/dl vs. 4.5 ±3.0 mg/dl) and UA (3.5 ±1.4 mg/dl vs. 5.7 ±0.7 mg/dl) levels, but lower mean FMD (5.6 ±2.4% vs. 4.8 ±2.0%) (p < 0.05 for all comparisons). No participant in normal UA group developed hypertension, while in hyperuricemia group, 6 participants developed hypertension. In hyperuricemia participants, after adjusted for covariates, per 1-standard deviation decrease in baseline FMD remained significantly associated with 15% increased risk of incident hypertension. Conclusions Patients with hyperuricemia have an increased risk of developing hypertension, and low baseline FMD in hyperuricemia patients is associated with significantly increased risk of incident hypertension.Chunli HanZhanchao XianYang ZouZhiyong LiaoRongfeng YangChunxia ZouXiaoqing WangYan SunTermedia Publishing Housearticlehypertensionflow-mediated dilationhyperuricemiaMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 343-349 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension flow-mediated dilation hyperuricemia Medicine R
spellingShingle	hypertension flow-mediated dilation hyperuricemia Medicine R Chunli Han Zhanchao Xian Yang Zou Zhiyong Liao Rongfeng Yang Chunxia Zou Xiaoqing Wang Yan Sun Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
description	Introduction The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia. Material and methods Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated dilation was assessed at baseline, and after 1 year’s follow-up the incidence of hypertension was compared between those with and without hyperuricemia. The predictive value of baseline FMD for incident hypertension among hyperuricemia patients was evaluated. Results A total of 222 participants were included. Mean systolic and diastolic blood pressure (BP) was 129.5 ±8.4 mm Hg and 78.3 ±7.9 mm Hg. Mean serum uric acid (UA) level was 4.4 ±2.8 mg/dl. Mean FMD was 5.1 ±2.7%. Compared to normal UA group, hyperuricemia group had higher proportion of male (58.4% vs. 61.2%), higher systolic BP (125.4 ±7.9 mm Hg vs. 132.1 ±7.3 mm Hg), serum high sensitivity C-reactive protein (3.9 ±2.2 mg/dl vs. 4.5 ±3.0 mg/dl) and UA (3.5 ±1.4 mg/dl vs. 5.7 ±0.7 mg/dl) levels, but lower mean FMD (5.6 ±2.4% vs. 4.8 ±2.0%) (p < 0.05 for all comparisons). No participant in normal UA group developed hypertension, while in hyperuricemia group, 6 participants developed hypertension. In hyperuricemia participants, after adjusted for covariates, per 1-standard deviation decrease in baseline FMD remained significantly associated with 15% increased risk of incident hypertension. Conclusions Patients with hyperuricemia have an increased risk of developing hypertension, and low baseline FMD in hyperuricemia patients is associated with significantly increased risk of incident hypertension.
format	article
author	Chunli Han Zhanchao Xian Yang Zou Zhiyong Liao Rongfeng Yang Chunxia Zou Xiaoqing Wang Yan Sun
author_facet	Chunli Han Zhanchao Xian Yang Zou Zhiyong Liao Rongfeng Yang Chunxia Zou Xiaoqing Wang Yan Sun
author_sort	Chunli Han
title	Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
title_short	Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
title_full	Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
title_fullStr	Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
title_full_unstemmed	Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
title_sort	flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/c95fa6fb0ac2467e8b483cda965940bc
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Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia

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