Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort

Abstract Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants...

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Autores principales:	Mareike Ernst, Elmar Brähler, Daniëlle Otten, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Felix Wicke, Jörg Wiltink, Matthias Michal, Markus Nagler, Thomas Münzel, Philipp S. Wild, Jochem König, Norbert Pfeiffer, Andreas Borta, Karl J. Lackner, Manfred E. Beutel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c961a442937041229ac6dd220b06e361
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spelling	oai:doaj.org-article:c961a442937041229ac6dd220b06e3612021-12-02T13:57:58ZInflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort10.1038/s41598-021-81927-92045-2322https://doaj.org/article/c961a442937041229ac6dd220b06e3612021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81927-9https://doaj.org/toc/2045-2322Abstract Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.Mareike ErnstElmar BrählerDaniëlle OttenAntonia M. WernerAna N. TibubosIris ReinerFelix WickeJörg WiltinkMatthias MichalMarkus NaglerThomas MünzelPhilipp S. WildJochem KönigNorbert PfeifferAndreas BortaKarl J. LacknerManfred E. BeutelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mareike Ernst Elmar Brähler Daniëlle Otten Antonia M. Werner Ana N. Tibubos Iris Reiner Felix Wicke Jörg Wiltink Matthias Michal Markus Nagler Thomas Münzel Philipp S. Wild Jochem König Norbert Pfeiffer Andreas Borta Karl J. Lackner Manfred E. Beutel Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
description	Abstract Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.
format	article
author	Mareike Ernst Elmar Brähler Daniëlle Otten Antonia M. Werner Ana N. Tibubos Iris Reiner Felix Wicke Jörg Wiltink Matthias Michal Markus Nagler Thomas Münzel Philipp S. Wild Jochem König Norbert Pfeiffer Andreas Borta Karl J. Lackner Manfred E. Beutel
author_facet	Mareike Ernst Elmar Brähler Daniëlle Otten Antonia M. Werner Ana N. Tibubos Iris Reiner Felix Wicke Jörg Wiltink Matthias Michal Markus Nagler Thomas Münzel Philipp S. Wild Jochem König Norbert Pfeiffer Andreas Borta Karl J. Lackner Manfred E. Beutel
author_sort	Mareike Ernst
title	Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
title_short	Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
title_full	Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
title_fullStr	Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
title_full_unstemmed	Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
title_sort	inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c961a442937041229ac6dd220b06e361
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Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort

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