Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles

Stavroula G Nanaki1, Kostas Pantopoulos2, Dimitrios N Bikiaris11Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece; 2Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Mo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nanaki SG, Pantopoulos K, Bikiaris DN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c961e8c182684930a49dfa0941d2e0ea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c961e8c182684930a49dfa0941d2e0ea
record_format	dspace
spelling	oai:doaj.org-article:c961e8c182684930a49dfa0941d2e0ea2021-12-02T05:00:26ZSynthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles1176-91141178-2013https://doaj.org/article/c961e8c182684930a49dfa0941d2e0ea2011-11-01T00:00:00Zhttp://www.dovepress.com/synthesis-of-biocompatible-polyepsilon-caprolactone-block-polypropylen-a8715https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Stavroula G Nanaki1, Kostas Pantopoulos2, Dimitrios N Bikiaris11Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece; 2Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: Poly(propylene adipate)-block-poly(&epsilon;-caprolactone) copolymers were synthesized using a combination of polycondensation and ring-opening polymerization of &epsilon;-caprolactone in the presence of poly(propylene adipate). Gel permeation chromatography was used for molecular weight determination, whereas hydrogen-1 nuclear magnetic resonance and carbon-13 nuclear magnetic resonance spectroscopy were employed for copolymer characterization and composition evaluation. The copolymers were found to be block while their composition was similar to the feeding ratio. They formed semicrystalline structures, while only poly(&epsilon;-caprolactone) formed crystals, as shown by wide angle X-ray diffraction. Differential scanning calorimetry data suggest that the melting point and heat of fusion of copolymers decreased by increasing the poly(propylene adipate) amount. The synthesized polymers exhibited low cytotoxicity and were used to encapsulate desferrioxamine, an iron-chelating drug. The desferrioxamine nanoparticles were self-assembled into core shell structures, had mean particle size &lt;250 nm, and the drug remained in crystalline form. Further studies revealed that the dissolution rate was mainly related to the melting temperature, as well as to the degree of crystallinity of copolymers.Keywords: biocompatible polyesters, poly(&epsilon;-caprolactone), poly(propylene adipate), drug encapsulation, desferrioxamineNanaki SGPantopoulos KBikiaris DNDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2981-2995 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Nanaki SG Pantopoulos K Bikiaris DN Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
description	Stavroula G Nanaki1, Kostas Pantopoulos2, Dimitrios N Bikiaris11Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece; 2Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: Poly(propylene adipate)-block-poly(&epsilon;-caprolactone) copolymers were synthesized using a combination of polycondensation and ring-opening polymerization of &epsilon;-caprolactone in the presence of poly(propylene adipate). Gel permeation chromatography was used for molecular weight determination, whereas hydrogen-1 nuclear magnetic resonance and carbon-13 nuclear magnetic resonance spectroscopy were employed for copolymer characterization and composition evaluation. The copolymers were found to be block while their composition was similar to the feeding ratio. They formed semicrystalline structures, while only poly(&epsilon;-caprolactone) formed crystals, as shown by wide angle X-ray diffraction. Differential scanning calorimetry data suggest that the melting point and heat of fusion of copolymers decreased by increasing the poly(propylene adipate) amount. The synthesized polymers exhibited low cytotoxicity and were used to encapsulate desferrioxamine, an iron-chelating drug. The desferrioxamine nanoparticles were self-assembled into core shell structures, had mean particle size &lt;250 nm, and the drug remained in crystalline form. Further studies revealed that the dissolution rate was mainly related to the melting temperature, as well as to the degree of crystallinity of copolymers.Keywords: biocompatible polyesters, poly(&epsilon;-caprolactone), poly(propylene adipate), drug encapsulation, desferrioxamine
format	article
author	Nanaki SG Pantopoulos K Bikiaris DN
author_facet	Nanaki SG Pantopoulos K Bikiaris DN
author_sort	Nanaki SG
title	Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
title_short	Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
title_full	Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
title_fullStr	Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
title_full_unstemmed	Synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
title_sort	synthesis of biocompatible poly(&epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/c961e8c182684930a49dfa0941d2e0ea
work_keys_str_mv	AT nanakisg synthesisofbiocompatiblepolyampepsiloncaprolactoneblockpolypropyleneadipatecopolymersappropriatefordrugnanoencapsulationintheformofcoreshellnanoparticles AT pantopoulosk synthesisofbiocompatiblepolyampepsiloncaprolactoneblockpolypropyleneadipatecopolymersappropriatefordrugnanoencapsulationintheformofcoreshellnanoparticles AT bikiarisdn synthesisofbiocompatiblepolyampepsiloncaprolactoneblockpolypropyleneadipatecopolymersappropriatefordrugnanoencapsulationintheformofcoreshellnanoparticles
_version_	1718400853123006464

Synthesis of biocompatible poly(&amp;epsilon;-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles

Ejemplares similares

Synthesis of biocompatible poly(ε-caprolactone)-block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles