Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?

Objectives: To describe the clinical characteristics of hip involvement in juvenile idiopathic arthritis (JIA) from arthritis to hip osteoarthritis (HOA) and total hip arthroplasty (THA).Study Design: Seven hundred fifty-three patients aged 2–17 years with JIA were included in the study. The compari...

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Autores principales:	Lubov S. Sorokina, Ilia S. Avrusin, Rinat K. Raupov, Natalia A. Lubimova, Sergey V. Khrypov, Mikhail M. Kostik
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	juvenile idiopathic arthritis hip osteoarthritis total hip arthroplasty corticosteroids avascular osteonecrosis of the femoral head Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/c9622ba82602400fb19f3b5f526649c7
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spelling	oai:doaj.org-article:c9622ba82602400fb19f3b5f526649c72021-11-05T11:08:08ZHip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?2296-236010.3389/fped.2021.747779https://doaj.org/article/c9622ba82602400fb19f3b5f526649c72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.747779/fullhttps://doaj.org/toc/2296-2360Objectives: To describe the clinical characteristics of hip involvement in juvenile idiopathic arthritis (JIA) from arthritis to hip osteoarthritis (HOA) and total hip arthroplasty (THA).Study Design: Seven hundred fifty-three patients aged 2–17 years with JIA were included in the study. The comparison analysis was performed between the following subgroups: (i) JIA without hip involvement (n = 600; 79.7%) vs. JIA with hip involvement without HOA (n = 105; 13.9%), (ii) JIA with hip involvement with HOA, but without THA (n = 32; 4.3%) and JIA with hip involvement with HOA and with THA (n = 16; 2.1%). Clinical, laboratory characteristics and treatment regimens compared.Results: Hip involvement was present in 20.3% of patients. HOA was present in 6.4% (121,000 patient-years) of the entire JIA group and 31.4% of patients with hip involvement. Sixteen patients (2.1%; 4.01,000 patient-years) required THA. The following factors were associated with HOA: sJIA (OR = 3.6, p = 0.008; HR = 3.0, p = 0.002), delayed remission (OR = 4.2, p = 0.004; HR = 1.4, p = 0.538), delay in biologic therapy initiation (OR = 7.5, p = 0.00001; HR = 6.7, p = 0.002), alkaline phosphatase <165 U\l (OR = 4.1, p = 0.0003; HR = 5.2, p = 0.000004), treatment with corticosteroids (CS) (OR = 2.6, p = 0.008; HR = 1.2, p = 0.670), cumulative corticosteroids >2,700 mg (OR = 4.3, p = 0.032; HR = 1.4, p = 0.527). The following factors were associated with THA: delay in biologic treatment initiation (OR = 1.04, p = 0.0001; HR = 9.1, p = 0.034), delayed hip involvement (OR = 5.2, p = 0.002; HR = 3.0, p = 0.044), and methylprednisolone pulse therapy (OR = 10.8, p = 0.0000001; HR = 5.6, p = 0.002).Conclusion: Both sJIA and systemic CS, impaired calcium-phosphorus metabolism, and delayed hip arthritis are associated with HOA development in JIA. HOA is considered to be a severe adverse event of CS treatment, especially delayed hip involvement.Lubov S. SorokinaIlia S. AvrusinRinat K. RaupovRinat K. RaupovRinat K. RaupovNatalia A. LubimovaSergey V. KhrypovMikhail M. KostikMikhail M. KostikFrontiers Media S.A.articlejuvenile idiopathic arthritiship osteoarthritistotal hip arthroplastycorticosteroidsavascular osteonecrosis of the femoral headPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	juvenile idiopathic arthritis hip osteoarthritis total hip arthroplasty corticosteroids avascular osteonecrosis of the femoral head Pediatrics RJ1-570
spellingShingle	juvenile idiopathic arthritis hip osteoarthritis total hip arthroplasty corticosteroids avascular osteonecrosis of the femoral head Pediatrics RJ1-570 Lubov S. Sorokina Ilia S. Avrusin Rinat K. Raupov Rinat K. Raupov Rinat K. Raupov Natalia A. Lubimova Sergey V. Khrypov Mikhail M. Kostik Mikhail M. Kostik Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?
description	Objectives: To describe the clinical characteristics of hip involvement in juvenile idiopathic arthritis (JIA) from arthritis to hip osteoarthritis (HOA) and total hip arthroplasty (THA).Study Design: Seven hundred fifty-three patients aged 2–17 years with JIA were included in the study. The comparison analysis was performed between the following subgroups: (i) JIA without hip involvement (n = 600; 79.7%) vs. JIA with hip involvement without HOA (n = 105; 13.9%), (ii) JIA with hip involvement with HOA, but without THA (n = 32; 4.3%) and JIA with hip involvement with HOA and with THA (n = 16; 2.1%). Clinical, laboratory characteristics and treatment regimens compared.Results: Hip involvement was present in 20.3% of patients. HOA was present in 6.4% (121,000 patient-years) of the entire JIA group and 31.4% of patients with hip involvement. Sixteen patients (2.1%; 4.01,000 patient-years) required THA. The following factors were associated with HOA: sJIA (OR = 3.6, p = 0.008; HR = 3.0, p = 0.002), delayed remission (OR = 4.2, p = 0.004; HR = 1.4, p = 0.538), delay in biologic therapy initiation (OR = 7.5, p = 0.00001; HR = 6.7, p = 0.002), alkaline phosphatase <165 U\l (OR = 4.1, p = 0.0003; HR = 5.2, p = 0.000004), treatment with corticosteroids (CS) (OR = 2.6, p = 0.008; HR = 1.2, p = 0.670), cumulative corticosteroids >2,700 mg (OR = 4.3, p = 0.032; HR = 1.4, p = 0.527). The following factors were associated with THA: delay in biologic treatment initiation (OR = 1.04, p = 0.0001; HR = 9.1, p = 0.034), delayed hip involvement (OR = 5.2, p = 0.002; HR = 3.0, p = 0.044), and methylprednisolone pulse therapy (OR = 10.8, p = 0.0000001; HR = 5.6, p = 0.002).Conclusion: Both sJIA and systemic CS, impaired calcium-phosphorus metabolism, and delayed hip arthritis are associated with HOA development in JIA. HOA is considered to be a severe adverse event of CS treatment, especially delayed hip involvement.
format	article
author	Lubov S. Sorokina Ilia S. Avrusin Rinat K. Raupov Rinat K. Raupov Rinat K. Raupov Natalia A. Lubimova Sergey V. Khrypov Mikhail M. Kostik Mikhail M. Kostik
author_facet	Lubov S. Sorokina Ilia S. Avrusin Rinat K. Raupov Rinat K. Raupov Rinat K. Raupov Natalia A. Lubimova Sergey V. Khrypov Mikhail M. Kostik Mikhail M. Kostik
author_sort	Lubov S. Sorokina
title	Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?
title_short	Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?
title_full	Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?
title_fullStr	Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?
title_full_unstemmed	Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?
title_sort	hip involvement in juvenile idiopathic arthritis: a roadmap from arthritis to total hip arthroplasty or how can we prevent hip damage?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c9622ba82602400fb19f3b5f526649c7
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Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?

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