γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder related to neuroinflammation that is associated with increased risk of thrombosis. We aimed to evaluate γ' fibrinogen plasma level (an in vivo variant of fibrinogen) as a biomarker in ALS, and to test its role as a...

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Autores principales:	Ana Catarina Pronto-Laborinho, Catarina S. Lopes, Vasco A. Conceição, Marta Gromicho, Nuno C. Santos, Mamede de Carvalho, Filomena A. Carvalho
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	amyotrophic lateral sclerosis prognosis respiratory function survival gamma' fibrinogen Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/c9651e3d5cfd4b42b63dfcebc338e867
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spelling	oai:doaj.org-article:c9651e3d5cfd4b42b63dfcebc338e8672021-11-12T16:30:51Zγ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis2297-055X10.3389/fcvm.2021.715842https://doaj.org/article/c9651e3d5cfd4b42b63dfcebc338e8672021-09-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.715842/fullhttps://doaj.org/toc/2297-055XAmyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder related to neuroinflammation that is associated with increased risk of thrombosis. We aimed to evaluate γ' fibrinogen plasma level (an in vivo variant of fibrinogen) as a biomarker in ALS, and to test its role as a predictor of disease progression and survival. Sixty-seven consecutive patients with ALS were followed and the results were compared with those from 82 healthy blood donors. Patients were clinically evaluated at the time of blood sampling and on follow-up (every 3 months for the beginning of the follow-up until death) by applying the revised ALS Functional Rating Scale. Human plasma γ' fibrinogen concentration was quantified using a specific two-site sandwich kit enzyme-linked immunosorbent assay. We found, for the first time, a positive association between γ' fibrinogen concentration and survival in ALS patients: patients with higher γ' fibrinogen plasma levels survived longer, and this finding was not influenced by confounders such as age, gender, respiratory impairment, or functionality (ALSFRS-R score). Since increased levels have a positive impact on outcome, this novel biomarker should be further investigated in ALS.Ana Catarina Pronto-LaborinhoCatarina S. LopesVasco A. ConceiçãoMarta GromichoNuno C. SantosMamede de CarvalhoMamede de CarvalhoFilomena A. CarvalhoFrontiers Media S.A.articleamyotrophic lateral sclerosisprognosisrespiratory functionsurvivalgamma' fibrinogenDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyotrophic lateral sclerosis prognosis respiratory function survival gamma' fibrinogen Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	amyotrophic lateral sclerosis prognosis respiratory function survival gamma' fibrinogen Diseases of the circulatory (Cardiovascular) system RC666-701 Ana Catarina Pronto-Laborinho Catarina S. Lopes Vasco A. Conceição Marta Gromicho Nuno C. Santos Mamede de Carvalho Mamede de Carvalho Filomena A. Carvalho γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis
description	Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder related to neuroinflammation that is associated with increased risk of thrombosis. We aimed to evaluate γ' fibrinogen plasma level (an in vivo variant of fibrinogen) as a biomarker in ALS, and to test its role as a predictor of disease progression and survival. Sixty-seven consecutive patients with ALS were followed and the results were compared with those from 82 healthy blood donors. Patients were clinically evaluated at the time of blood sampling and on follow-up (every 3 months for the beginning of the follow-up until death) by applying the revised ALS Functional Rating Scale. Human plasma γ' fibrinogen concentration was quantified using a specific two-site sandwich kit enzyme-linked immunosorbent assay. We found, for the first time, a positive association between γ' fibrinogen concentration and survival in ALS patients: patients with higher γ' fibrinogen plasma levels survived longer, and this finding was not influenced by confounders such as age, gender, respiratory impairment, or functionality (ALSFRS-R score). Since increased levels have a positive impact on outcome, this novel biomarker should be further investigated in ALS.
format	article
author	Ana Catarina Pronto-Laborinho Catarina S. Lopes Vasco A. Conceição Marta Gromicho Nuno C. Santos Mamede de Carvalho Mamede de Carvalho Filomena A. Carvalho
author_facet	Ana Catarina Pronto-Laborinho Catarina S. Lopes Vasco A. Conceição Marta Gromicho Nuno C. Santos Mamede de Carvalho Mamede de Carvalho Filomena A. Carvalho
author_sort	Ana Catarina Pronto-Laborinho
title	γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis
title_short	γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis
title_full	γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis
title_fullStr	γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis
title_full_unstemmed	γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis
title_sort	γ' fibrinogen as a predictor of survival in amyotrophic lateral sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c9651e3d5cfd4b42b63dfcebc338e867
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γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis

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