Discrete SARS-CoV-2 antibody titers track with functional humoral stability

The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elic...

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Autores principales:	Yannic C. Bartsch, Stephanie Fischinger, Sameed M. Siddiqui, Zhilin Chen, Jingyou Yu, Makda Gebre, Caroline Atyeo, Matthew J. Gorman, Alex Lee Zhu, Jaewon Kang, John S. Burke, Matthew Slein, Matthew J. Gluck, Samuel Beger, Yiyuan Hu, Justin Rhee, Eric Petersen, Benjamin Mormann, Michael de St Aubin, Mohammad A. Hasdianda, Guruprasad Jambaulikar, Edward W. Boyer, Pardis C. Sabeti, Dan H. Barouch, Boris D. Julg, Elon R. Musk, Anil S. Menon, Douglas A. Lauffenburger, Eric J. Nilles, Galit Alter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9653ceb7d9e4c3a8933d1abc7322637
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spelling	oai:doaj.org-article:c9653ceb7d9e4c3a8933d1abc73226372021-12-02T12:11:39ZDiscrete SARS-CoV-2 antibody titers track with functional humoral stability10.1038/s41467-021-21336-82041-1723https://doaj.org/article/c9653ceb7d9e4c3a8933d1abc73226372021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21336-8https://doaj.org/toc/2041-1723The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elicited receptor-binding domain (RBD)-specific antibody titers above a certain threshold, suggesting that development of T cell responses to be related to anti-RBD Ab production.Yannic C. BartschStephanie FischingerSameed M. SiddiquiZhilin ChenJingyou YuMakda GebreCaroline AtyeoMatthew J. GormanAlex Lee ZhuJaewon KangJohn S. BurkeMatthew SleinMatthew J. GluckSamuel BegerYiyuan HuJustin RheeEric PetersenBenjamin MormannMichael de St AubinMohammad A. HasdiandaGuruprasad JambaulikarEdward W. BoyerPardis C. SabetiDan H. BarouchBoris D. JulgElon R. MuskAnil S. MenonDouglas A. LauffenburgerEric J. NillesGalit AlterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yannic C. Bartsch Stephanie Fischinger Sameed M. Siddiqui Zhilin Chen Jingyou Yu Makda Gebre Caroline Atyeo Matthew J. Gorman Alex Lee Zhu Jaewon Kang John S. Burke Matthew Slein Matthew J. Gluck Samuel Beger Yiyuan Hu Justin Rhee Eric Petersen Benjamin Mormann Michael de St Aubin Mohammad A. Hasdianda Guruprasad Jambaulikar Edward W. Boyer Pardis C. Sabeti Dan H. Barouch Boris D. Julg Elon R. Musk Anil S. Menon Douglas A. Lauffenburger Eric J. Nilles Galit Alter Discrete SARS-CoV-2 antibody titers track with functional humoral stability
description	The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elicited receptor-binding domain (RBD)-specific antibody titers above a certain threshold, suggesting that development of T cell responses to be related to anti-RBD Ab production.
format	article
author	Yannic C. Bartsch Stephanie Fischinger Sameed M. Siddiqui Zhilin Chen Jingyou Yu Makda Gebre Caroline Atyeo Matthew J. Gorman Alex Lee Zhu Jaewon Kang John S. Burke Matthew Slein Matthew J. Gluck Samuel Beger Yiyuan Hu Justin Rhee Eric Petersen Benjamin Mormann Michael de St Aubin Mohammad A. Hasdianda Guruprasad Jambaulikar Edward W. Boyer Pardis C. Sabeti Dan H. Barouch Boris D. Julg Elon R. Musk Anil S. Menon Douglas A. Lauffenburger Eric J. Nilles Galit Alter
author_facet	Yannic C. Bartsch Stephanie Fischinger Sameed M. Siddiqui Zhilin Chen Jingyou Yu Makda Gebre Caroline Atyeo Matthew J. Gorman Alex Lee Zhu Jaewon Kang John S. Burke Matthew Slein Matthew J. Gluck Samuel Beger Yiyuan Hu Justin Rhee Eric Petersen Benjamin Mormann Michael de St Aubin Mohammad A. Hasdianda Guruprasad Jambaulikar Edward W. Boyer Pardis C. Sabeti Dan H. Barouch Boris D. Julg Elon R. Musk Anil S. Menon Douglas A. Lauffenburger Eric J. Nilles Galit Alter
author_sort	Yannic C. Bartsch
title	Discrete SARS-CoV-2 antibody titers track with functional humoral stability
title_short	Discrete SARS-CoV-2 antibody titers track with functional humoral stability
title_full	Discrete SARS-CoV-2 antibody titers track with functional humoral stability
title_fullStr	Discrete SARS-CoV-2 antibody titers track with functional humoral stability
title_full_unstemmed	Discrete SARS-CoV-2 antibody titers track with functional humoral stability
title_sort	discrete sars-cov-2 antibody titers track with functional humoral stability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9653ceb7d9e4c3a8933d1abc7322637
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Discrete SARS-CoV-2 antibody titers track with functional humoral stability

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