Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice

Introduction: Depression and anxiety are the most common psychiatric disorders. These conditions widely occur in industrial societies and severely affect individuals’ lives. N-Acetylcysteine (NAC) is a mucolytic compound with antioxidant and anti-inflammatory effects. This study aimed to investigate...

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Autores principales:	Yavar Mahmoodzadeh, Javad Mahmoudi, Sattar Gorgani-Firuzjaee, Naser Mohtavinejad, Ali Namvaran
Formato:	article
Lenguaje:	EN
Publicado:	Iran University of Medical Sciences 2021
Materias:	noise stress depression anxiety n-acetylcysteine oxidative stress Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c965f1c87a4e4d65a4b1582b45d0a2cf
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spelling	oai:doaj.org-article:c965f1c87a4e4d65a4b1582b45d0a2cf2021-12-05T08:43:44ZEffects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice2008-126X2228-7442https://doaj.org/article/c965f1c87a4e4d65a4b1582b45d0a2cf2021-07-01T00:00:00Zhttp://bcn.iums.ac.ir/article-1-1596-en.htmlhttps://doaj.org/toc/2008-126Xhttps://doaj.org/toc/2228-7442Introduction: Depression and anxiety are the most common psychiatric disorders. These conditions widely occur in industrial societies and severely affect individuals’ lives. N-Acetylcysteine (NAC) is a mucolytic compound with antioxidant and anti-inflammatory effects. This study aimed to investigate the potential therapeutic effects of NAC on chronic noise-induced depression- and anxiety-like behaviors in mice. Methods: Fifty male BALB/c mice were randomly divided into 5 groups, as follows: control, noise90 dB, noise110 dB, noise 90+NAC, and noise 110+NAC groups. Animals in the noise groups were exposed to 90 dB 2 h/day and 110 dB 2 h/day for 30 days. The NAC groups received NAC (325 mg/kg P.O.) 20 min after being exposed to noise. To evaluate depressive- and anxiety-like behaviors, the examined mice were subjected to the Open Field Test (OFT), Sucrose Preference Test (SPT), Tail Suspension Test (TST), and Elevated Plus Maze (EPM) tasks. At the end of the behavioral tests, the study animals were sacrificed. Accordingly, the levels of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) were determined in the Hippocampus (HIP) and the Prefrontal Cortex (PFC). Results: The obtained results suggested that noise exposure would induce anxiety- and depressive-like behaviors, being reversed by NAC administration. Moreover, chronic administration of NAC significantly increased antioxidant enzyme activities and reduced lipid peroxidation (MDA levels) in the PFC and HIP of noise-exposed mice. Conclusion: Our findings revealed that administrating NAC would reduce the adverse effects of noise on the brain and would exert anti-depressant and anxiolytic effects.Yavar MahmoodzadehJavad MahmoudiSattar Gorgani-FiruzjaeeNaser MohtavinejadAli NamvaranIran University of Medical Sciencesarticlenoise stressdepressionanxietyn-acetylcysteineoxidative stressNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBasic and Clinical Neuroscience, Vol 12, Iss 4, Pp 499-510 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	noise stress depression anxiety n-acetylcysteine oxidative stress Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	noise stress depression anxiety n-acetylcysteine oxidative stress Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yavar Mahmoodzadeh Javad Mahmoudi Sattar Gorgani-Firuzjaee Naser Mohtavinejad Ali Namvaran Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice
description	Introduction: Depression and anxiety are the most common psychiatric disorders. These conditions widely occur in industrial societies and severely affect individuals’ lives. N-Acetylcysteine (NAC) is a mucolytic compound with antioxidant and anti-inflammatory effects. This study aimed to investigate the potential therapeutic effects of NAC on chronic noise-induced depression- and anxiety-like behaviors in mice. Methods: Fifty male BALB/c mice were randomly divided into 5 groups, as follows: control, noise90 dB, noise110 dB, noise 90+NAC, and noise 110+NAC groups. Animals in the noise groups were exposed to 90 dB 2 h/day and 110 dB 2 h/day for 30 days. The NAC groups received NAC (325 mg/kg P.O.) 20 min after being exposed to noise. To evaluate depressive- and anxiety-like behaviors, the examined mice were subjected to the Open Field Test (OFT), Sucrose Preference Test (SPT), Tail Suspension Test (TST), and Elevated Plus Maze (EPM) tasks. At the end of the behavioral tests, the study animals were sacrificed. Accordingly, the levels of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) were determined in the Hippocampus (HIP) and the Prefrontal Cortex (PFC). Results: The obtained results suggested that noise exposure would induce anxiety- and depressive-like behaviors, being reversed by NAC administration. Moreover, chronic administration of NAC significantly increased antioxidant enzyme activities and reduced lipid peroxidation (MDA levels) in the PFC and HIP of noise-exposed mice. Conclusion: Our findings revealed that administrating NAC would reduce the adverse effects of noise on the brain and would exert anti-depressant and anxiolytic effects.
format	article
author	Yavar Mahmoodzadeh Javad Mahmoudi Sattar Gorgani-Firuzjaee Naser Mohtavinejad Ali Namvaran
author_facet	Yavar Mahmoodzadeh Javad Mahmoudi Sattar Gorgani-Firuzjaee Naser Mohtavinejad Ali Namvaran
author_sort	Yavar Mahmoodzadeh
title	Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice
title_short	Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice
title_full	Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice
title_fullStr	Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice
title_full_unstemmed	Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice
title_sort	effects of n-acetylcysteine on noise exposure-induced oxidative stress and depressive- and anxiety-like behaviors in adult male mice
publisher	Iran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/c965f1c87a4e4d65a4b1582b45d0a2cf
work_keys_str_mv	AT yavarmahmoodzadeh effectsofnacetylcysteineonnoiseexposureinducedoxidativestressanddepressiveandanxietylikebehaviorsinadultmalemice AT javadmahmoudi effectsofnacetylcysteineonnoiseexposureinducedoxidativestressanddepressiveandanxietylikebehaviorsinadultmalemice AT sattargorganifiruzjaee effectsofnacetylcysteineonnoiseexposureinducedoxidativestressanddepressiveandanxietylikebehaviorsinadultmalemice AT nasermohtavinejad effectsofnacetylcysteineonnoiseexposureinducedoxidativestressanddepressiveandanxietylikebehaviorsinadultmalemice AT alinamvaran effectsofnacetylcysteineonnoiseexposureinducedoxidativestressanddepressiveandanxietylikebehaviorsinadultmalemice
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Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice

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