Inactivation of <italic toggle="yes">thyA</italic> in <named-content content-type="genus-species">Staphylococcus aureus</named-content> Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene Expression

Inactivation of <italic toggle="yes">thyA</italic> in <named-content content-type="genus-species">Staphylococcus aureus</named-content> Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene Expression

ABSTRACT Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs) are frequently isolated from patients with chronic S. aureus infections after long-term treatment with trimethoprim-sulfamethoxazole (TMP-SMX). While it has been shown that TD-SCVs were associated with mutations in th...

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Autores principales: Andre Kriegeskorte, Desiree Block, Mike Drescher, Nadine Windmüller, Alexander Mellmann, Cathrin Baum, Claudia Neumann, Nicola Ivan Lorè, Alessandra Bragonzi, Eva Liebau, Patrick Hertel, Jochen Seggewiss, Karsten Becker, Richard A. Proctor, Georg Peters, Barbara C. Kahl
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c969432815d641ee9c487fbaa84ee179
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