Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study

Gedefaw Diress,1 Melese Linger2 1Department of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia; 2Department of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Gedefaw Diress Department of Public HealthCollege of Health Sciences...

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Autores principales:	Diress G, Linger M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	adherence anti-retroviral therapy hiv viral load Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c969b0ec6a504ccda448afb8a37eef84
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spelling	oai:doaj.org-article:c969b0ec6a504ccda448afb8a37eef842021-12-02T16:09:04ZChange in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study1179-1373https://doaj.org/article/c969b0ec6a504ccda448afb8a37eef842020-12-01T00:00:00Zhttps://www.dovepress.com/change-in-viral-load-count-and-its-predictors-among-unsuppressed-viral-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Gedefaw Diress,1 Melese Linger2 1Department of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia; 2Department of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Gedefaw Diress Department of Public HealthCollege of Health Sciences, Woldia University, Woldia 400, EthiopiaTel +251913756945Email gedefawdiress@gmail.comBackground: Enhanced adherence counseling (EAC) is an interventional program that provides targeted adherence counseling for unsuppressed viral load people living with HIV who are receiving antiretroviral therapy before diagnosing treatment failure. However, there is a lack of evidence on change in viral load count among patients receiving EAC intervention. Therefore, this study aimed to assess change in viral load count and its predictors among people living with HIV (PLHIV) in northeast Ethiopia.Methods: A hospital-based retrospective follow-up study was conducted on 235 randomly selected patients with unsuppressed viral load who started EAC sessions between 2016 and 2019 at three governmental hospitals in the northern part of Ethiopia. Viral load count and patient individual factors were assessed at EAC program enrollment and viral load counts repeated at the end of EAC session. The main outcome variable was a change in viral load count during the EAC session period. A paired sample t-test was used to determine the mean difference in viral load count before and after EAC intervention. Linear mixed-effects models were used to assess the effect of selected factors on viral load count change.Results: Based on the paired sample t-test, there was a significant mean difference in viral load count before and after EAC intervention (mean difference=16,904, (95% CI: 9986– 23,821; p-value< 0.001). The multivariable linear mixed-effects regression analysis showed that young age (β= 0.03; 95% CI: 0.01, 0.14), urban residence (β= − 0.55; 95% CI: − 0.63, − 0.34), CD4 count of 201– 500 cells/mm3 (β= − 0.67; 95% CI: − 0.87, − 0.43) and long duration on ART (β= − 0.01; 95% CI: − 0.01, − 0.02) were associated with the decline in viral load count.Conclusion: We detected a substantial decline in viral load count among patients receiving an EAC intervention. Young age, urban residence, CD4 count of 201– 500 cells/mm3 and long duration on ART were the positive predictors of viral load suppression.Keywords: adherence, anti-retroviral therapy, HIV, viral loadDiress GLinger MDove Medical Pressarticleadherenceanti-retroviral therapyhivviral loadImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 869-877 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	adherence anti-retroviral therapy hiv viral load Immunologic diseases. Allergy RC581-607
spellingShingle	adherence anti-retroviral therapy hiv viral load Immunologic diseases. Allergy RC581-607 Diress G Linger M Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study
description	Gedefaw Diress,1 Melese Linger2 1Department of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia; 2Department of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Gedefaw Diress Department of Public HealthCollege of Health Sciences, Woldia University, Woldia 400, EthiopiaTel +251913756945Email gedefawdiress@gmail.comBackground: Enhanced adherence counseling (EAC) is an interventional program that provides targeted adherence counseling for unsuppressed viral load people living with HIV who are receiving antiretroviral therapy before diagnosing treatment failure. However, there is a lack of evidence on change in viral load count among patients receiving EAC intervention. Therefore, this study aimed to assess change in viral load count and its predictors among people living with HIV (PLHIV) in northeast Ethiopia.Methods: A hospital-based retrospective follow-up study was conducted on 235 randomly selected patients with unsuppressed viral load who started EAC sessions between 2016 and 2019 at three governmental hospitals in the northern part of Ethiopia. Viral load count and patient individual factors were assessed at EAC program enrollment and viral load counts repeated at the end of EAC session. The main outcome variable was a change in viral load count during the EAC session period. A paired sample t-test was used to determine the mean difference in viral load count before and after EAC intervention. Linear mixed-effects models were used to assess the effect of selected factors on viral load count change.Results: Based on the paired sample t-test, there was a significant mean difference in viral load count before and after EAC intervention (mean difference=16,904, (95% CI: 9986– 23,821; p-value< 0.001). The multivariable linear mixed-effects regression analysis showed that young age (β= 0.03; 95% CI: 0.01, 0.14), urban residence (β= − 0.55; 95% CI: − 0.63, − 0.34), CD4 count of 201– 500 cells/mm3 (β= − 0.67; 95% CI: − 0.87, − 0.43) and long duration on ART (β= − 0.01; 95% CI: − 0.01, − 0.02) were associated with the decline in viral load count.Conclusion: We detected a substantial decline in viral load count among patients receiving an EAC intervention. Young age, urban residence, CD4 count of 201– 500 cells/mm3 and long duration on ART were the positive predictors of viral load suppression.Keywords: adherence, anti-retroviral therapy, HIV, viral load
format	article
author	Diress G Linger M
author_facet	Diress G Linger M
author_sort	Diress G
title	Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study
title_short	Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study
title_full	Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study
title_fullStr	Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study
title_full_unstemmed	Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study
title_sort	change in viral load count and its predictors among unsuppressed viral load patients receiving an enhanced adherence counseling intervention at three hospitals in northern ethiopia: an exploratory retrospective follow-up study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c969b0ec6a504ccda448afb8a37eef84
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Change in Viral Load Count and Its Predictors Among Unsuppressed Viral Load Patients Receiving an Enhanced Adherence Counseling Intervention at Three Hospitals in Northern Ethiopia: An Exploratory Retrospective Follow-Up Study

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